تغییرات فورین، CTRP-12، TNF-α و پروفایل لیپیدی به هشت هفته تمرین هوازی تناوبی و مقاومتی در زنان دیابتی نوع دو

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

3 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

چکیده

 
استراتژی‌های کنترل فورین، فاکتورهای التهابی و همچنین افزایش مقادیر CTRP-12، در پیشگیری و درمان اختلالات متابولیکی مرتبط با چاقی و دیابت مؤثر است. از جمله استراتژی‌های مؤثر، تمرین ورزشی است. ازاین‌رو هدف پژوهش حاضر بررسی تأثیر 8 هفته تمرین هوازی تناوبی و مقاومتی بر مقادیر فورین، CTRP-12، TNF-α و پروفایل لیپیدی در زنان دیابتی نوع دو بود. 30 زن دیابتی (09/5 ± 9/51 سال)، به‌طور تصادفی به دو گروه تمرین (هوازی تناوبی و مقاومتی) و یک گروه کنترل تقسیم شدند. گروه‌های تمرین به مدت 8 هفته و 3 جلسه در هفته تمرین ورزشی هوازی تناوبی و مقاومتی را انجام دادند. مقادیر فورین، CTRP-12، TNF-α و پروفایل لیپیدی با استفاده از کیت به روش ELISA اندازه‌گیری شد. برای تجزیه‌وتحلیل داده‌ها از آزمون آماری ANCOVA در سطح معناداری 05/0 >P استفاده شد. نتایج آزمون تحلیل کوواریانس نشان داد که در متغیر فورین (046/0 P =، 472/3= F) و CTRP-12 (016/0 P =، 893/4= F) بین گروه‌های پژوهش پس از 8 هفته مداخله تفاوت معنا‌داری وجود داشت. نتایج آزمون تعقیبی LSD نشان داد، تمرین مقاومتی نسبت به گروه کنترل موجب کاهش معنا‌دار فورین (020/0 P =) و افزایش معنا‌دار CTRP-12 (004/0 P =) شد. این در حالی بود که معنا‌داری TNF-a تأیید نشد (055/0 P =، 245/3= F). به‌نظر می‌رسد تغییرات CTRP-12 با تمرین مقاومتی در نمونۀ دیابتی به مقدار بیشتر تحت تأثیر فورین و به مقدار کمتر تحت تأثیر آدیپوکاین التهابی TNF-α قرار می‌گیرد، که این مسیر مقاومت به انسولین را نیز کنترل می‌کند.

کلیدواژه‌ها


عنوان مقاله [English]

Furin, CTRP-12, TNF-α and Lipid Profile Changes during 8 Weeks of Aerobic Interval and Resistance Training in Women with Type 2 Diabetes

نویسندگان [English]

  • Ebrahim Froozandeh 1
  • Asghar Tofighi 2
  • Javad Tolouei azar 3
1 PhD Student of Exercise Physiology, Urmia University
2 Associate Professor of Exercise Physiology, Urmia University
3 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
چکیده [English]

Strategies of furin control, inflammatory factors and also increased CTRP-12 are effective to prevent and treat metabolic disorders associated with obesity and diabetes. One of the effective strategies is training. Therefore, the aim of this study was to investigate the effect of 8 weeks of aerobic interval and resistance training on levels of furin, CTRP-12, TNF-α and lipid profile in type 2 diabetic women. 30 diabetic women (51.9 ± 5.09 years) were randomly divided into two groups of training (aerobic interval and resistance) and one control group. The training groups performed aerobic interval and resistance training for 8 weeks and 3 sessions per week. Furin, CTRP-12, TNF-α, and lipid profile were measured using ELISA kit.  Data were analyzed by ANCOVA at the significance level (P<0.05). The results of ANCOVA showed a significant difference between the study groups after 8 weeks of intervention in the furin (P=0.046, F=3.472) and CTRP-12 (P=0.016, F=4.893). The results of LSD post hoc test showed that resistance training significantly decreased furin (P=0.020) and CTRP-12 (P=0.004) compared with the control group. However, the significance of TNF-a was not confirmed (P=0.055, F=3.245). It seems that changes of CTRP-12 with resistance training are more affected by furin and less affected by TNF-α inflammatory adipokine in diabetic patients. This pathway controls insulin resistance as well.

کلیدواژه‌ها [English]

  • Aerobic interval training
  • CTRP-12
  • diabetic women
  • furin
  • resistance training
  • TNF-α
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