بررسی اثرات ضدالتهابی و ضد دردی مصرف کوتاه‌مدت خوراکی داروی ایندومتاسین در بهبود علائم بیوشیمیایی، ظاهری و عملکردی کوفتگی عضلانی تأخیری

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزشی، دانشکدۀ تربیت ‌بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

2 دانشجوی دکتری فیزیولوژی ورزشی، گروه تربیت ‌بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

3 کارشناس‌ارشد، حرکات اصلاحی و آسیب‌شناسی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه خوارزمی، تهران، ایران

4 استاد فیزیولوژی ورزشی، گروه تربیت‌ بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

5 کارشناس‌ارشد، فیزیولوژی ورزش، دانشکدۀ تربیت ‌بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

چکیده

هدف مطالعۀ حاضر، بررسی اثرات مصرف خوراکی داروی ایندومتاسین در بهبود کوفتگی عضلانی تأخیری بود. 20 مرد سالم، به دو گروه مساوی تجربی و کنترل تقسیم شدند. گروه تجربی روزانه سه کپسول 25 میلی­گرمی ایندومتاسین و کنترل، دارونما دریافت کردند. در مراحل قبل، 1، 24، 48 و 72 ساعت پس از انجام پروتکل تمرینی، متغیرها اندازه‎گیری شدند. پس از مصرف سه روز کپسول ایندومتاسین و دارونما، پروتکل تمرینی با 85% 1RM در چهار نوبت و هر نوبت تا سر حد واماندگی اجرا شد. برای بررسی نتایج از روش آماری تحلیل واریانس با اندازه­گیری مکرر استفاده شد. نتایج کاهش معنا­داری در غلظت آنزیم CK و LDH و میزان درد و التهاب در گروه ایندومتاسین نسبت به گروه کنترل نشان داد. حداکثر نیروی ایزوتونیک گروه تجربی در مقایسه با گروه کنترل کاهش کمتر و معنا‎داری را نشان داد. دامنۀ حرکتی زانو گروه ایندومتاسین نسبت به گروه کنترل التهاب کمتری داشت. می‎توان گفت که مصرف ایندومتاسین در دورۀ بازگشت به حالت اولیه تأثیرات مفیدی در بهبود DOMS دارد.

کلیدواژه‌ها


عنوان مقاله [English]

An Investigation of Anti-Inflammatory and Analgesic Effects of Short-Term Oral Consumption of Indomethacin on Improving Biochemical, Morphological and Functional Symptoms of DOMS

نویسندگان [English]

  • ali akbarnejad 1
  • ALI Rajabi 2
  • Edris Bavardi Moghadam 3
  • Marefat Siahkouhian 4
  • morteza yari 5
1 Exercise Physiology, Faculty of physical education and sport sciences, Tehran University, Tehran, Iran
2 Department of Physical Education and Resource Science, Ardebil University, Ardebil, Iran
3 Faculty of sport sciences, Kharazmi University, Tehran, Iran.
4 Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
5 Exercise Physiology, Faculty of physical education and sport sciences, Tehran University, Tehran, Iran
چکیده [English]

 
The aim of this study was to investigate the effects of oral administration of indomethacin on improving delayed onset muscle soreness) DOMS(. 20 healthy men were divided into two equal groups: experimental and control. The experimental group received 3 capsules of indomethacin (each capsule 25 mg) and control group received placebo daily. Before and 1, 24, 48 and 72 hours after the exercise protocol, the variables were measured. After the consumption of indomethacin or placebo capsules for 3 days, the exercise protocol was performed with 85% 1RM in four sets and every set until exhaustion. The analysis of variance with repeated measures was used to analyze the results. The results showed a significant reduction in CK and LDH enzyme concentration and pain and inflammation in the indomethacin group compared with the control group. Maximal isotonic force showed lower and significant reduction in the experimental group than the control group. Knee range of motion in the indomethacin group had less inflammation than the control group. It can be said that the consumption of indomethacin during recovery has beneficial effects on improving DOMS.

کلیدواژه‌ها [English]

  • indomethacin
  • Inflammation
  • Pain
  • CPK
  • delayed onset muscle soreness
  • LDH

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