بررسی اثرات ضدالتهابی و ضد دردی مصرف کوتاه‌مدت خوراکی داروی ایندومتاسین در بهبود علائم بیوشیمیایی، ظاهری و عملکردی کوفتگی عضلانی تأخیری

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشیار فیزیولوژی ورزشی، دانشکدۀ تربیت ‌بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

2 دانشجوی دکتری فیزیولوژی ورزشی، گروه تربیت ‌بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

3 کارشناس‌ارشد، حرکات اصلاحی و آسیب‌شناسی ورزشی، دانشکدۀ علوم ورزشی، دانشگاه خوارزمی، تهران، ایران

4 استاد فیزیولوژی ورزشی، گروه تربیت‌ بدنی و علوم ورزشی، دانشگاه محقق اردبیلی، اردبیل، ایران

5 کارشناس‌ارشد، فیزیولوژی ورزش، دانشکدۀ تربیت ‌بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

چکیده

هدف مطالعۀ حاضر، بررسی اثرات مصرف خوراکی داروی ایندومتاسین در بهبود کوفتگی عضلانی تأخیری بود. 20 مرد سالم، به دو گروه مساوی تجربی و کنترل تقسیم شدند. گروه تجربی روزانه سه کپسول 25 میلی­گرمی ایندومتاسین و کنترل، دارونما دریافت کردند. در مراحل قبل، 1، 24، 48 و 72 ساعت پس از انجام پروتکل تمرینی، متغیرها اندازه‎گیری شدند. پس از مصرف سه روز کپسول ایندومتاسین و دارونما، پروتکل تمرینی با 85% 1RM در چهار نوبت و هر نوبت تا سر حد واماندگی اجرا شد. برای بررسی نتایج از روش آماری تحلیل واریانس با اندازه­گیری مکرر استفاده شد. نتایج کاهش معنا­داری در غلظت آنزیم CK و LDH و میزان درد و التهاب در گروه ایندومتاسین نسبت به گروه کنترل نشان داد. حداکثر نیروی ایزوتونیک گروه تجربی در مقایسه با گروه کنترل کاهش کمتر و معنا‎داری را نشان داد. دامنۀ حرکتی زانو گروه ایندومتاسین نسبت به گروه کنترل التهاب کمتری داشت. می‎توان گفت که مصرف ایندومتاسین در دورۀ بازگشت به حالت اولیه تأثیرات مفیدی در بهبود DOMS دارد.

کلیدواژه‌ها


عنوان مقاله [English]

An Investigation of Anti-Inflammatory and Analgesic Effects of Short-Term Oral Consumption of Indomethacin on Improving Biochemical, Morphological and Functional Symptoms of DOMS

نویسندگان [English]

  • ali akbarnejad 1
  • ALI Rajabi 2
  • Edris Bavardi Moghadam 3
  • Marefat Siahkouhian 4
  • morteza yari 5
1 Exercise Physiology, Faculty of physical education and sport sciences, Tehran University, Tehran, Iran
2 Department of Physical Education and Resource Science, Ardebil University, Ardebil, Iran
3 Faculty of sport sciences, Kharazmi University, Tehran, Iran.
4 Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
5 Exercise Physiology, Faculty of physical education and sport sciences, Tehran University, Tehran, Iran
چکیده [English]

 
The aim of this study was to investigate the effects of oral administration of indomethacin on improving delayed onset muscle soreness) DOMS(. 20 healthy men were divided into two equal groups: experimental and control. The experimental group received 3 capsules of indomethacin (each capsule 25 mg) and control group received placebo daily. Before and 1, 24, 48 and 72 hours after the exercise protocol, the variables were measured. After the consumption of indomethacin or placebo capsules for 3 days, the exercise protocol was performed with 85% 1RM in four sets and every set until exhaustion. The analysis of variance with repeated measures was used to analyze the results. The results showed a significant reduction in CK and LDH enzyme concentration and pain and inflammation in the indomethacin group compared with the control group. Maximal isotonic force showed lower and significant reduction in the experimental group than the control group. Knee range of motion in the indomethacin group had less inflammation than the control group. It can be said that the consumption of indomethacin during recovery has beneficial effects on improving DOMS.

کلیدواژه‌ها [English]

  • indomethacin
  • Inflammation
  • Pain
  • CPK
  • delayed onset muscle soreness
  • LDH
Jeon HSKang SYPark JHLee HS. "Effects of pulsed electromagnetic field therapy on delayed-onset muscle soreness in biceps brachii". Physical Therapy in Sport. 2015; 16(1):34-9. 
Bilal D, Metin Y, Asim C, Nazmi S, Mehmet G. "Comparison of Ice Massage versus Cold-Water Immersion on Muscle Damage and DOMS Levels of Elite Wrestlers". T-ANTH. 2015; 19(1): 123-129.
Pumpa KLFallon KEBensoussan APapalia S. "The effects of Lyprinol on delayed onset muscle soreness and muscle damage in well trained athletes: A double-blind randomised controlled trial". Complementary Therapies in Medicine. 2011; 19(6): 311-318.
Meamarbashi A, Rajabi A. "Preventive Effects of 10-Day Supplementation with Saffron and Indomethacin on the Delayed-Onset Muscle Soreness". Clinical Journal of Sport Medicine. 2015; 25(2): 105–112.
Pearcey GEBradbury-Squires DJKawamoto JEDrinkwater EJBehm DGButton DC. "Foam Rolling for Delayed-Onset Muscle Soreness and Recovery of Dynamic Performance Measures". Journal of Athletic. 2015; 50(1): 5–13.
Azadeh N, Hadi A, Hasan M, Ali D, Foad A. "The Effect of Single Portion Glutamine Supplement Consumption on Injury Indices of Muscle After Eccentric Resistance Exercise." Arak Medical University Journal (AMUJ). 2015; 18(97): 9-17. (In Persian)
Abramson S, Korchak H, Ludewig R, Edelson H, Haines K, Levin RI, et al. "Modes of action of aspirin-like drugs". PNAS. 1985; 82(21):7227-31.
Pyne DB. "Exercise-induced muscle damage and inflammation: a review". Australian journal of science and medicine in sport. 1994; 26(3-4): 49-58.
Rhind SGGannon GASuzui MShephard RJShek PN. "Indomethacin inhibits circulating PGE2 and reverses postexercise suppression of natural killer cell activity". Am J Physiol. 1999; 276(5-2): 1496-505.
Shafat A, Butler P, Jensen L, Donnelly E. "Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans". European Journal of Applied Physiology. 2004; 93(1-2): 196-202.
Malanga GAYan NStark J. "Mechanisms and efficacy of heat and cold therapies for musculoskeletal injury". Postgrad Med. 2015; 127(1):57-65.
Tartibian B, Derafshi B. "The effect of Indomethacin on the biochemical, functional and visual appearance of delayed muscular tachycardia due to eccentric contractions in non-athlete men." Journal of Sport Sciences. 2009; 3: 110-93. (In Persian)
Itoh KKawakita K. "Effect of indomethacin on the development of eccentric exercise-induced localized sensitive region in the fascia of the rabbit". Jpn J Physiol. 2002; 52(2):173-80.
Tiidus PM. "Massage and ultrasound as therapeutic modalities in exercise induced muscle damage". Journal of Applied Physiology. 1999; 24(3): 267-78.
Dareanosh F, KHadejeh H, Hagheghe M. "The effect of short duration of ginger extract on delayed muscular fatigue after a training session in girls." Sports Physiology. 2012; 13: 108-89. (In Persian)
Meamarbashi A, Abedini F. "Preventive effects of purslane extract on delayed onset muscle soreness induced by one session bench-stepping exercise". Isokinetics and Exercise Science. 2011; 19(3): 199-206.
Arbabian S, Ezadi H, GHoshnavi H." The effect of aqueous extract of saffron on chronic pain induced by formalin test in female laboratory mice". 2009; 14(1): 11-18. (In Persian)
Tokmakidis SP, Kokkinidis EA, Smilios IDouda H. "The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise". JSCR. 2003; 17(1):53-9.
Talag TS. "Residual muscular soreness as influenced by concentric, eccentric and static contraction". Research Quarterly for Exercise and Sport. 1973; 44(4): 458-469.
Meamarbashi A, Rajabi A. "The effects of peppermint on exercise performance". J Int Soc Sports Nutr. 2013; 10(1):15. 
Tartibian B, Maleki BH, Abbasi A. "The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men". Clinical Journal of Sport Medicine. 2009; 19(2):115-119.
Cannavino CRAbrams JPalinkas LASaglimbeni ABracker MD. "Efficacy of transdermal ketoprofen for delayed onset muscles oreness". Clinical Journal of Sport Medicine.  2003; 13(4):200-8.
Marginson V, Rowlands AV, Gleeson NP, Eston RG. "Comparison of the symptoms of exercise-induced muscle damage after an initial and repeated bout of plyometric exercise in men and boys". Journal of Applied Physiology. 2005; 99(3):1174-81.
Nicol LMRowlands DSFazakerly RKellett J. "Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)". European Journal of Applied Physiology. 2015; 115(8): 1769-77.
Victor M, Patrick J, Connor G, Kevin k. "Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise". Clinical Journal of Sport Medicine. 2007; 8(3): 237-243.
Stone MB, Merrick MA, Ingersol CD, Edwards JE. "Preliminary comparision of bromelain and ibuprofen for delayed onset muscle soreness management". Clin J of Sport Med. 2002; 12(6): 373-378.
Tartibian B, Azizbeigi K."The Effect of Taking Naproxen Drug on the Level of Perceived Pain and Changes of CPK Serum after Eccentric exercise." World journal of sport sciences. 2008; 37: 77-92. (In Persian)
Turk DCDworkin RH. "What should be the core outcomes in chronic pain clinical trials?" Epub. 2004; 6(4):151-4.
Boardman PL, Dudley HF. "effects of indomethacin". Ann rheum. 1967; 26: 127-132.
Peterson JM, Trappe TA, Mylona E, White FLambert CPEvans WJ, et al. "Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise". MSSE. 2003; 35(6):892-6.