تأثیر فعالیت استقامتی با حجم بالا در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ مویرگ زایی در مردان غیرفعال

نویسندگان

1 کارشناس ارشد فیزیولوژی و تغذیه ورزشی دانشگاه تهران

2 استاد دانشگاه تهران

3 استادیار دانشگاه تهران

4 کارشناس ارشد دانشگاه بوعلی سینا

چکیده

تمرینات ورزشی باعث تغییرات فیزیولوژیکی و بیوشیمیایی گسترده ای در بدن می شوند که از جمله این تغییرات می توان به افزایش چگالی  مویرگی یا آنژیوژنز در بافت عضله اسکلتی و عضله قلبی اشاره کرد. VEGF به عنوان مهمترین فاکتور آنژیوژنیکی جهت رخداد فرایندهای آنژیوژنزی شناخته شده است، لذا هدف از انجام تحقیق حاضر بررسی تاثیر یک جلسه فعالیت استقامتی طولانی مدت در شرایط هایپوکسی نورموباریک و نورموکسی بر پاسخ مویرگ زایی در مردان غیر فعال می باشد.به این منظور 8 مرد جوان غیر فعال (سن 5/0±25 سال و قد 4/5±174سانتی متر، وزن 5/4±62کیلوگرم؛ حداکثر بازده کاری (Wmax) در شرایط هایپوکسی 41/13±159و در شرایط نورموکسی21/8±171 به عنوان آزمودنی انتخاب شدند. آزمودنی‌ها پروتکل فعالیت تداومی را در شرایط هایپوکسی نورموباریک (3/15 تا 5/15 درصداکسیژن تقریباً برابر ارتفاع 2500 متر) و همین پروتکل را در شرایط نورموکسی در دو هفته مجزا اجرا کردند. نمونه های خونی قبل، بلافاصله و 2 ساعت بعد از فعالیت گرفته شد. نتایج آزمون تحلیل واریانس با اندازه گیری‌های مکرر نشان داد که بین شرایط محیطی مختلف (هایپوکسی و نورموکسی)، درمیزاناثرگذاریبرسطوحVEGFسرمی مردان غیر فعال اختلاف معنادار وجود دارد(036/0P=). مداخلات تمرینی و مطالعات بسیاری برای مشخص شدن مویرگ زایی در بدن نیاز است. اگرچه سطوح بالای VEGFبعد از فعالیت تداومی در شرایط هایپوکسی به نسبت شرایط نورموکسی ممکن است منجر به افزایش آنژیوژنز و مویرگ زایی شود. به هر حال مطالعات آینده برای مشخص شدن محرک‌ها و مکانیسم‌هایی که برای رشد عروق جدید در تمرینات تداومی که گزارش شده نیازمند است.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of High Volume Endurance Exercise (HVE) during Normobaric Hypoxia and Normoxia on Angiogenesis Response in Inactive Men

نویسندگان [English]

  • Yaghoub Mehri Alvar 1
  • Ali Asghar Ravasi 2
  • Fatemeh Shabkhiz 3
  • Fahimeh Erfani Adab 4
  • Sajjad Hasanvand 1
1 MSc. of Exercise Physiology and Nutrition, University of Tehran, Tehran, Iran
2 Professor, University of Tehran, Tehran, Iran
3 Assistant Professor, University of Tehran, Tehran, Iran
4 MSc., Bu-Ali Sina University, Hamedan, Iran
چکیده [English]

Exercise training induces vast physiological and biochemical changes in the body such as an increase in capillary density or angiogenesis of muscular and cardiac tissues. VEGF is known as the most important angiogenic factor in the occurrence of angiogenesis processes. Thus the aim of this study was to investigate the effect of a single bout of long endurance exercise on in normobaric hypoxia and normoxia conditions on angiogenesis response of inactive men. 8 inactive young men (age 25±0.5 yr, height 174±5.4 cm, weight 62 ±4.5 kg and maximum work output (Wmax) in hypoxia condition 159±13.41 and in normoxia condition 171±8.21) were selected as the subjects. Subjects performed the protocol of continuous exercise in normobarichypoxia condition (%15.3-15.5 O2, altitude of approximately 2500 m) and performed the same protocol in normoxia condition during two separate weeks. Blood samples were collected before, immediately and two hours after the exercise. The results of ANOVA with repeated measures showed a significant difference between hypoxia and normoxia conditions in the amount of the effectiveness on serum VEGF levels in inactive men (P=0.036). Training interventions and many studies are needed to determine angiogenesis in human body. Although high levels of VEGF after continuous exercise may increase angiogenesis in hypoxia condition compared with normoxia condition, future studies are needed to determine the incentives and mechanisms necessary for the growth of new blood arteries in continuous exercises.
 

کلیدواژه‌ها [English]

  • High Volume Endurance Exercise
  • hypoxia
  • Angiogenesis
  • Vascular Endothelial Growth Factor
  • Vessels

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