عنوان تأثیر 12 هفته تمرین به همراه مکمل امگا بر سطوح سرمی کمرین و شاخص مقاومت به انسولین در زنان چاق غیرفعال

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی دانشگاه آزاد اسلامی، واحد علوم تحقیقات، گروه تربیت بدنی، تهران، ایران

2 .استاد دانشگاه شهید بهشتی، دانشکدة تربیت بدنی، تهران، ایران،

3 دانشیار دانشگاه آزاد اسلامی، واحد علوم تحقیقات، گروه تربیت بدنی، تهران، ایران

چکیده

 
هدف تحقیق حاضر، بررسی تاثیر 12 هفته تمرین هوازی فزاینده به همراه مکمل امگا بر سطوح سرمی کمرین و شاخص مقاومت به انسولین در زنان چاق غیر فعال بود. در این مطالعه نیمه تجربی، 32  نفر از زنان چاق غیر فعال (سن 3 ± 36 سال و شاخص  توده بدن 5.23 ± 35.52  kg/m2)، که هیچ گونه فعالیت بدنی منظمی نداشتند، به عنوان آزمودنی های تحقیق انتخاب و به طور تصادفی در چهار گروه 8 نفری:  تمرین (T)، تمرین - امگا (T-OM)، امگا (OM) و کنترل (C) تقسیم شدند. آزمودنی های گروه  T و T-OM تمرینات هوازی فزاینده را با شدت 60 تا 80% حد اکثر ضربان قلب هر فرد، سه جلسه در هفته و به مدت 12 هفته انجام دادند. همچنین آزمودنی های گروه T-OM و OM، هر هفته 7 کپسول هر کدام حاوی هزار میلی گرم امگا-3 و آزمودنی های گروه T و C نیز در همین مدت دارو نما مصرف کردند. نمونه های خونی ناشتایی قبل و بعد از 12 هفته تمرین هوازی و مصرف مکمل جمع آوری شد. نتایج آزمون آماری تحلیل واریانس دو راهه نشان داد، تعامل تمرین-  امگا منجر به کاهش معنادار سطوح سرمی کمرین )0/010 (P=، و بهبود شاخص مقاومت به انسولین
)0/010 (P=و گلوگز  )0/004 (P=در زنان چاق غیر فعال می شود. مداخله ی توام تمرین- امگا منجر به کاهش بیشتر سطوح سرمی کمرین ؛درمقایسه با اثر تمرین و امگا به صورت مجزا؛ در زنان چاق غیر فعال می شود، اما به نظر می رسد این تعامل در رابطه با بهبود بیشتر شاخص مقاومت به انسولین تاثیر کمتری داشته باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 12 Weeks of Training with Omega Supplement on Serum Levels of Chemerin and Insulin Resistance in Obese Inactive Women

نویسندگان [English]

  • Tayebeh Mohammadikhou 1
  • Khosro Ebrahim 2
  • Hojjatollah Nikbakht 3
1 PhD Student in Exercise Physiology, Islamic Azad University, Science and Research Branch, Department of Physical Education, Tehran, Iran
2 Professor at Shahid Beheshti University, Faculty of Physical Education, Tehran, Iran
3 Associate Professor at Islamic Azad University, Science and Research Branch, Department of Physical Education, Tehran, Iran
چکیده [English]

The aim of this study was to examine the effect of 12 weeks of progressive aerobic training with omega supplement on serum levels of chemerin and insulin resistance in obese inactive women. In this semi-experimental study, 32 obese inactive women (age 36 ± 3 yr, body mass index 35.52 ± 5.23 kg/m2) who had no regular physical activity were selected as the sample and randomly divided into four groups of 8 subjects: training (T), training - omega (T-OM), omega (OM) and control (C). The subjects in groups T and T-OM performed progressive aerobic training at an intensity corresponding to 60-80% of maximum heart rate 3 days/week for 12 weeks. The subjects in groups T-OM and OM consumed 7 omega-3 capsules, each containing 1000 mg omega-3 every week and subjects in groups T and C consumed placebo during the same period. Fasting blood samples were taken before and after 12 weeks of aerobic training and supplementation. Results of two-way ANOVA demonstrated the interaction of training – omega significantly reduced serum levels of chemerin (P=0.010) and improved insulin resistance index (P=0.010) and glucose (P=0.004) in obese inactive women. Compared with the effect of training and omega separately, the combined intervention of training - omega led to a further reduction in serum levels of chemerin in obese inactive women, but this interaction appears to be less effective in relation to the further improvement of insulin resistance index.

کلیدواژه‌ها [English]

  • adipokine
  • Obesity
  • Omega-3 fatty acids
  • insulin resistance
  • progressive aerobic training
  1. Asgari, R. (1391). Compared the combination and endurance exercise on plasma Vaspin, chemerin, visfatin and insulin sensitivity index in overweight girls. PhD thesis .Physical Education and Sports Science, Faculty of Physical Education and Sports Science, Tehran University, Tehran, Iran. Pp. 40-65.
  2. Bozaoglu K, Segal D, Shields KA, Cummings N, Curran JE, Comuzzie AG, et al. (2009). Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population. J Clin Endocrinol Metab; 94: 3085-8.
  3. Bozaoglu, K. et al. (2007). Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 148, 4687–4694.
  4.  Bruun JM, Helge JW, Richelsen B, Stallknecht B. (2006). Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiology Endocrinology. 290: E961-7.
  5. Carmela, R. B. Calogero, C. Giuseppina, C. (2010). The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Hindawi Publishing Corporation Mediators of Inflammation, Article ID 802078, 19 pages.
6. Davidson L, Hudson R, Kilpatrick K, Kuk J, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R.(2009). Effects of exercise modality on insulin resistance and functional limitation in older adults. Arch Intern Med. 169(20: 122-31.

 7. Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, Hoseini M, Parizade SM, Farhoudi F, et al. (2009). Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol; 64:321–7.

8.Espsito K, Giugliano F. (2004). Effect off life style changes on erectile dysfunction in obese men. JAMA: The journal of the American Medical Association, 291: 2978-83.

9.Friedenreich C, Neilson H, Woolcott C, Tiernan A, Wang Q, Ballard-Barbash R, Jones CA,Stanczyk FZ, Brant RF, Yasui Y, et al. (2011). Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr Relat Cancer. 18(3): 357-69.

10.Giamila F.(2005). Adipose tissue, adipokines, and inflamemation. J Allergy Clin Immunology; 115: 911-19.

11.Goralski, K.B. et al. (2007). Chemerin,  a novel adipokine that regulates adipogenesis and adipocyte metabolism. J. Biol. Chem. 282, 28175–28188

12.Hawley JA. (2004). Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes Metab Res Rev; 20: 383-93.

13. Hemant P, Sunil K. Panchal, Vishal D, Lindsay B. (2011). Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action. School of Biomedicalsciences, The universityof Queensland, Qld4072, Australia. Progress in Lipid Research 50, 372–387.

14.Irving BA, Davis CK, Brock DW, Weltman JY, Swift D, Barrett EJ, et al. (2008). Effect of exercise training intensity on abdominal visceral fat and body composition. Med Sci Sports Exerc; 40: 1863-72.

15.Kirk EA, Sagawa ZK, McDonald TO, O'Brien KD, Heinecke JW. (2008). Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]. Diabetes; 57: 1254-61.

16.Lakka TA, Laaksonen DE. (2007). Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab; 32: 76-88.

17.Lee KJ, Shin YA, Lee KY, Jun TW, Song W. (2010). Aerobic exercise training-induced decrease in plasma visfatin and insulin resistance in obese female adolescents. Int J Sport Nutr Exerc Metab. 20(4): 275-81.

18.MacDougald OA, Burant CF. (2007). The rapidly expanding family of adipokines. Cell Metab; 6: 159-61.

19.Malek shahi moghadam, A. (1390).  Effects ofsupplementationwith omega-3 fatty acids on  Il-2, TNF –  and CRP in patients with type 2 diabetes. PhD veterinary Medicine, Faculty of Veterinary Medicine, Tehran University of Medical Sciences , Tehran, Iran. Journal of Faculty Health and Research Institute of Beheshti. Number 3. Pp. 73-81.

20.Matthew C. Ernst and Christopher J. Sinal. (2010). Chemerin: at the crossroads of inflammation and obesity. Department of Pharmacology, Dalhousie university, Halifax, nova scotia, canada. Trends in Endocrinology and Metabolism, vol. 21 No.11, 660-667.

21.Micallef M, Munro I, Phang M, Garg M. (2009). Plasma n_3 polyunsaturated fatty acids are negatively associated with obesity. Br J Nutr; 102:1370–4.

22. Pischon, T. Hankinson, S.E., Hotamisligil, G.S., Rifai, N., Willett, W.C. and Rimm, E.B. (2003). Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation, 108(2), pp.155-160.  

23.Rima, C. et al. (2012). Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity. Department Of Medicine, university ofLeipzig, Germany. metabolism clinical and experimental, 61, pages 706-714.

24.Saremi, A.  et al. (2010). Twelve-Week Aerobic Training Decreases Chemerin Level and ImprovesCardiometabolic Risk Factors in Overweight and Obese Men. PhD ,Physical Education and Sports Science, Faculty of Physical Education and Sports Science, Arak University, Arak, Iran. Asian Journal of Sports Medicine, Vol 1 (No 3), Pages: 151-158.

25.Saremi, A. , et al. (1389). The effect of 12 weeks of strength training on serum chemerin, C-reactive protein and tumor necrosis factor-alpha in patients with metabolic syndrome. PhD ,Physical Education and Sports Science, Faculty of Physical Education and Sports Science, Arak University, Arak, Iran. Iranian Journal of Endocrinology and Metabolism. Number 5. Pp. 536-543

26.Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, et al. (2009). Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cell. Diabetes; 58: 2731-40.

27.Shin HY, Lee Dc, Chu SH, Jeon JY. (2011). Chemerin levels are positively correlated with abdominal visceral fat accumulation. Clin Endocrinal (OXF). 2; doi: 10. 1111Lj.

28.Shirin-Zadeh, M., et al. (1388). Nutritional value and adequacy of food intake in patients with type 2 diabetes. Iranian Journal of Endocrinology and Metabolism. 11 period. Number 1. Pp. 25-32.

29.Tartibian B, Hajizadeh Maleki B, Kanaley J, Sadeghi K. (2011). Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study. Associate Professor ,Physical Education and Sports Science, Faculty of Physical Education and Sports Science, Oromiye University, Oromiye, Iran. Nutr Metab Lond).;8:71.

30.Tartibian, B. Maleki, H. Abbasi, A. (2011). Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men. Associate Professor ,Physical Education and Sports Science, Faculty of Physical Education and Sports Science, Oromiye University, Oromiye, Iran. Clinical Journal of Sport. Medicine, vol. 21, no. 2, pp. 131–137.

31.Vermi, W. et al. (2005). Role  of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J. Exp. Med. 201, 509–515.

32.Wittamer, V. et al. (2003). Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 198, 977–985.

33.Zabel, B.A. et al. (2005). Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J. Immunology l. 174, 244–251.