تأثیر8 هفته تمرین هوازی بر سطوح ALT ،AST ، مقادیر انسولین و گلوکز ناشتا در مردان مبتلا به استئاتوهپاتیت غیر الکلی

نویسندگان

1 کارشناسی ارشد فیزیولوژی ورزشی گروه تربیت بدنی، دانشگاه آزاد اسلامی، واحد خوراسگان، اصفهان ، ایران

2 استادیار فیزیولوژی ورزشی گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد خوراسگان، اصفهان ، ایران .

چکیده

استئاتوهپاتیت غیرالکلی یک اختلال کبدی همراه با تجمع تری گلیسیرید در کبد است و مرتبط با سندروم متابولیکی از قبیل چاقی، دیابت قندی و هایپرلیپیدمیا است.هدف از پژوهش حاضر، بررسی تاثیر 8 هفته تمرینات هوازی، برسطوحALT ، AST، انسولین و گلوکز ناشتا درمبتلایان به استئاتوهپاتیت غیرالکلی بود. 20 فرد بیمار به دو گروه تمرین هوازی و گروه کنترل(10=n) تقسیم شدند. گروه تمرین هوازی به مدت 8 هفته، هر هفته 3 جلسه، شامل10 دقیقه گرم کردن، دویدن با شدت 55 تا 75 درصد ضربان قلب بیشینه و 5 دقیقه سرد کردن شرکت نمودند. نمونه خون وریدی آن ها قبل و پس از 8 هفته تمرین در هر دو گروه جمع آوری شد. جهت تحلیل آماری از تحلیل واریانس مکرر(ANOVA) با عامل بین گروهی(2*2) استفاده شد. نتایج این مطالعه در گروه تمرین هوازی کاهش معنادار در سطوح سرمی(000/0=P) ALT و(001/0=P) AST،گلوکز ناشتا(024/0=P) و انسولین ناشتا(000/0=P)، شاخص مقاومت به انسولین(000/0=P)، اندازه دور کمر (04/0=P)، وزن(033/0=P)  و شاخص توده بدنی(03/0=P) را نشان داد، اما در گروه کنترل تغییری دیده نشد. با توجه به مطالعه حاضر، برنامهتمرین هوازی کنترل شده می تواند روش درمانی مفید برای بیماران استئاتوهپاتیت غیرالکلی باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 8 Weeks of Aerobic Training on ALT , AST, Insulin and Fasting Glucose Levels in Nonalcoholic Steatohepatitis Men

نویسندگان [English]

  • Akram Rashidi 1
  • Gholam Reza Sharifi 2
1 MSc of Exercise Physiology, Department of Physical Education, Islamic Azad University , Khorasgan Branch, Isfahan, Iran
2 Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Islamic Azad University , Khorasgan Branch, Isfahan, Iran
چکیده [English]

Nonalcoholic steatohepatitis is a liver disorder that is accompanied with accumulation of triglyceride in hepatocyte and is related to metabolic syndromes such as obesity, diabetes mellitus and hyperlipidemia. The aim of this study was to investigate the effect of 8 weeks of  aerobic training on ALT ,AST, insulin and fasting glucose levels in the patients suffering from nonalcoholic steatohepatitis. 20 patients were divided into two groups: aerobic training (n=10) and control (n=10). Aerobic training protocol included warm-up (10 min.), running (55-75% of maximum heart rate) and cool-down (5 min.) for 8 weeks, 3 sessions per week. Blood samples were collected before and after 8 weeks of training in both groups. All data were analyzed using ANOVA with repeated measures with intergroup factor) 2*2(. The results showed that serum levels of ALT (P=0.000), AST (P=0.001), fasting glucose (P=0.024), fasting insulin (P=0.000), insulin resistance (P=0.000), waist (P=0.04), weight (P=0.033) and body mass index (P=0.03) significantly decreased in aerobic training group,  but no changes were observed in the control group. Considering the present study, a controlled aerobic training protocol can be a helpful treatment for nonalcoholic steatohepatitis patients. 

کلیدواژه‌ها [English]

  • aerobic training
  • ALT
  • AST
  • fasting glucose
  • insulin
  • nonalcoholic steatohepatitis
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