اثر 8 هفته تمرینات مقاومتی دایره‌ای بر سطوح Ox-LDL، hs-CRP، HbA1c خون و شاخص مقاومت به انسولین در زنان یائسه غیرفعال

نویسندگان

1 استادیار گروه فیزیولوژی ورزش ، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران

2 کارشناس ارشد فیزیولوژی ورزش دانشگاه آزاد اسلامی واحد علوم و تحقیقات رشت، رشت، ایران

3 دانشجوی دکتری بیوشیمی و متابولیسم ورزشی دانشگاه اصفهان، اصفهان، ایران

چکیده

زمینه و هدف: افزایش سن و یائسگی در زنان منجر به بروز بیماری­های مزمن مختلفی می­شود که اجرای تمرینات بدنی منظم در بهبود اختلالات متابولیک، بیماری‌های قلبی- عروقی و شاخص‌های التهابی نقش موثری دارد. در مطالعه حاضر اثر هشت هفته برنامه تمرینات مقاومتی دایره‌ای بر سطوحلیپوپروتئین با چگالی کم اکسید شده (Ox-LDL)، پروتئین واکنشگر C با حساسیت بالا (hs-CRP)، هموگلوبین گلیکوزیله (HbA1c) خون و شاخص مقاومت به انسولین (HOMA-IR) در زنان یائسه غیرفعال مورد اندازه­گیری قرار گرفت. روش‌ تحقیق: 29 زن یائسه غیرفعال (سن 33/4 ± 83/55 سال) به‌طور تصادفی از بین افراد داوطلب انتخاب شدند. آزمودنی‌ها به دو گروه تمرین با تعداد 15 نفر (kg/m29/4±81/31=BMI) و گروه کنترل تعداد 14 نفر (kg/m278/3±22/30= BMI) تقسیم شدند. برنامه تمرینی شامل هشت هفته تمرینات مقاومتی دایره‌ای بود که 3 جلسه در هفته با شدت 75-60 درصد حداکثر1RM  و در هر جلسه بین 90-60 دقیقه اجرا شد. برای تجزیه و تحلیلداده­هاازآزمونآماری t مستقل، t همبسته و سطح معنی­داری 05/0P< استفاده شد. تجزیه و تحلیل داده­ها با نرم افزار SPSS نسخه 20 انجام شد. یافته‌ها: پس از 8 هفته، گلوکز ناشتا (035/0=p)، شاخص مقاومت به انسولین (05/0=p)، سطوح پروتئین واکنشگر C با حساسیت بالا (042/0=p)، کلسترول تام (035/0=p)، تری گلیسیرید (040/0=pLDL-C (01/0=p) و اسید اوریک (012/0=p) خونی در گروه تمرینات مقاومتی دایره­ای به طور معنی­داری کاهش یافته بود. همچنین بین سطوح پروتئین واکنشگر C با حساسیت بالا و LDL-C خونی در دو گروه تفاوت معنی­داری وجود داشت. نتیجه‌گیری: با توجه به یافته­های پژوهش حاضر به نظر می­رسد اجرای تمرینات مقاومتی دایره­ای می­تواند موجب کاهش عوامل ایجاد کننده اختلالات متابولیکی، قلبی- عروقی و عملکرد ایمنی در زنان یائسه شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 8 Weeks of Circuit Resistance Training on Ox-LDL, hs-CRP, HbA1c and Insulin Resistance Index in Sedentary Postmenopausal Women

نویسندگان [English]

  • Javad Mehrabani 1
  • Fereshteh Mirmohamadloo 2
  • Hadi Nobari 3
1 Assistant Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran
2 MSc of Exercise Physiology, Islamic Azad University, Rasht Science & Research Branch, Rasht, Iran
3 PhD Student of Biochemistry and Sport Metabolism, University of Isfahan, Isfahan, Iran
چکیده [English]

Aging and menopause lead to various chronic diseases in women. Regular physical exercise improves metabolic disorders, cardiovascular diseases and inflammatory markers. The aim of this study was to investigate the effect of 8 weeks of circuit resistance training on the oxidative low density lipoprotein (Ox-LDL), high sensitive C reactive protein (CRP), glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) in sedentary postmenopausal women. 29 sedentary postmenopausal women (age=55.83±4.33 years) were selected randomly from volunteers. Subjects were divided into two groups: a group with 15 patients (BMI=31.81±4.90 kg/m2) and a control group with 14 patients (BMI=30.22±3.78 kg/m2). The training program included an eight-week circuit resistance training conducted 3 sessions a week (60-90 minutes per session) with an intensity of %60-%75 of the maximum 1RM. For data analysis, the independent and dependent t tests were used. Significance level was set at P<0.05. Data were analyzed by SPSS20 software. After 8 weeks, fasting glucose (P=0.035), insulin resistance index (P=0.05), hs-CRP (P=0.042), total cholesterol (P=0.035), triglycerides (P=0.040), LDL-C (P=0.01) and uric acid (P=0.012) significantly decreased in the resistance training group. Also, there was a significant difference between hs-CRP and LDL-C in both groups. According to the results, it seems that circuit resistance training can reduce the causes of metabolic and cardiovascular disorders and immune function in postmenopausal women.

کلیدواژه‌ها [English]

  • circuit resistance training
  • insulin resistance index
  • hs-CRP
  • HbA1c
  • sedentary postmenopausal women

1.Anke, T., Scholz, M., Fasshauer, M., et al. (2007). Beneficial effects of a 4-week exercise a concentration of adhesion molecules. Diabetes Care. 30(3)e1.

2. Beckie, TM., Groer, JWP., Maureen, W. (2010). The influence of cardiac rehabilitation on inflammation and metabolic syndrome in women with coronary heart disease. J Cardiovas Nurs. 25(1):52-60.

3.Carlsohn, A., Rohn SA., Mayer F., Schweigert, FJ. (2010). Physical activity, antioxidant status, and protein modification in adolescent athletes. Med Sci Sports Exerc. 42(6): 1131-1139.

4.Caulin, GT., Farrell, WJ., Pfau, SE., Zaret, B., et al. (1998). Modulation of circulation cellular adhesion molecules in postmenopausal women with coronary artery disease. J Am Coll Cardiol. 31:1555-1560.

5.Chobine, S., Dabidi Roshan, V., Ghaeini A. (2007). The effect of continuous and intermittent aerobic exercise on the hs-CRP in wistar rats. Movement Sci Sport. 5(9):1-13. [persian].

6.Cornelissen, VA., Fagard, RH. (2005). Effects of endurance training on blood pressure, blood pressure-regulating mechanism, and cardiovascular risk factors. Hypertension. 46:667-675.

7.Dunstan, DW., Daly, RM., Owen, N., Jolley, D., et al. (2002). High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 25(10):1729-1736.

8.Ebrahim, Kh., Basaami, M., Kolahdozi, S., Karimnia, SV. (2012). The impact of resistance exercise on metabolism of fats and carbohydrates circle during endurance exercise in overweight men. Iranian J Endocrin Met. 14(3):257-266. [persian].

9.Eftekhari, M., Mozafari, KH. (2008). Effect of soybeans on homocysteine and serum lipoproteins in hyperlipidemic postmenopausal women. Iranian J Endocrin Met. 4:31-39. [persian].

10.Gibbs, BB., Devon, A., Dobrosielski, C., Susanne, BD, et al (2012). A randomized trial of exercise for blood pressure reduction in type 2 diabetes: effect on flow-mediated dilation and circulating biomarkers of endothelial function. Atherosclerosis. 224:446-53.

11.Haghighi, AH,. Mahmoudi, M., Delgosha, H. (2010). Hormonal responses to two programs of exhaustive resistance training of different intensities in male body builders. 14(3):267-274. [persian].

12.Kullo, IJ., Khaleghi, M., Hensrud, DD. (2007). Markers of inflammation are inversely associated with VO2 max in asymptomatic men. J Appl Physiol. 102:1374-1379.

13.Lee KJ, Shin YA, Lee KY, Jun TW and Song W. (2010). Aerobic exercise training-induced decrease in plasma visfatin and insulin resistance in obesity female adolescents. Int J Sport Nutr Exerc Metab. 20(4):275-281.

14.Lerch, PG., Spycher, MO., Doran, JE. (1998). Reconstituted high density lipoprotein (r-HDL) modulates platelet activity in vitro and ex vivo. Thrombo Haemost. 80:316-20.

15.Mattusch, F., Duffax, B., Heine O., Mertense I., Rost R. (2003). Reduction of the plasma concentration of C-reactive protein following nine month of endurance training: Int J Med. 21:21-24.

16.Mehrabani, J., Azimi, B., Khosravi A., Mehrabani F. (2011). The effect of 19 weeks of physical training on insulin resistance and high-sensitivity C-reactive protein in obese and non-obese. J Endocrin Met. 14(5):44-437 [persian].

17.Meyer, C., Pimenta, W., Woerle, HJ., et al. (2006). Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care. 29:1909-1914.

18.Naomi, B., Layne, JE., Gordon, PL., Roubenoff, R., et al. (2007). Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci. 4(1):19-27.

19.Nicklas, BJ., Ambrosius, W., Messier, SP., Miller, GD., et al. (2004). Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. Am J Clin Nutr. 79:544-451.

20.Olsan, TP., Dengel, DR., Leon, AS., Schmitz KH. (2007). Changes in Inflammatory Biomarkers Following One-Year of Moderate Resistance Training in Over Weight Women. International PF Obesity. 31:996-1003.

21.Ounis, O., Elloumi, M., Chiekh, I., et al. (2008). Effects of two-month physical-endurance and diet-restriction programmes on lipid profiles and insulin resistance in obese adolescent boys. Diabetes and Metabolism. 34:595-600.

22.Parsian, H., Ebrahim, Kh., Nikbakht, H., Khanali, F. (2012). The effect of 12 weeks of endurance training on serum C reactive protein and plasma fibrinogen as predictors of cardiovascular disease. Pajoohandeh J. 17(2):62-66 [persian].

23.Pedersen, BK. (2007). IL-6 signalling in exercise and disease. Biochem Soc T. 35:1295-1297.

24.Pitsavos, C., Panagiotakos, DB., Chrysohoou, C., Kavouras, S., Stefanadis, C. (2005). The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study. Eur J Cardiovasc Prev Rehabil. 12:151-158.

25.Roberts, C. K., Won, D., Pruthi, S., Kurtovic, S., et al. (2006). Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9 and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol. 100:1657-1665.

26.Sabatier, MJ., Schwark, EH., Lewis, R., Sloan, G., et al. (2008). Femoral artery remodeling after aerobic exercise training without weight loss in women. Dyn Med. 8:7-13.

27.Satoru, K., Shu, M., Nobuhiro, Y., and Hirohito, S. (2006). Exercise training for ameliorating cardiovascular risk factors-focusing on exercise intensity and amount. Int J Sport Health Sci. 4:325-338.

28.Schubert, A., Schuler, G., Hambrecht, R. (2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 42:861-868.

29.Stauffer, BL., Hoetzer, GL., Smith, DT., DeSouza, CA. (2004). Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. J Appl Physiol. 96(1):143-148.

30.Steinberger, J., Daniels, S. (2003). Obesity, insulin resistance, diabetes, and cardiovascular risk in children: An american heart association scientific statement from the atherosclerosis, hypertension, and obesity in the young committee (Council on cardiovascular disease in the young) and the diabetes committee. Council on nutrition, physical activity, and metabolism. Circulation, 107:1448-1453.

31.Tanko, LB., Bruun, JM., Alexandersen, P., et al. (2004). Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity implications for atherogenesis. J Am Heart Assoc. 110:2246-2252.

32.Witkowska, A M., Soluble, I. (2005). A marker of vascular inflammation and lifestyle. Cytokine. 31(2):127-134.

33.Wong, PCH., Chia, AYH., Tsou, IYY., Wansaicheong, GKL., et al. (2008). Effects of 12- weeks exercise training programme on aerobic fitness, body composition, blood lipids and C-reactive protein in adolescents with obesity. Ann Acad Med Singapore. 37:286-93.