تغییرات مقاومت به انسولین و رزیستین سرمی بعد از ۱۰ هفته تمرین تناوبی شدید در مردان دارای اضافه وزن و چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

1 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد تهران شرق، دانشگاه آزاد اسلامی تهران، ایران

2 دانشجوی دکتری،دانشکده علوم ورزشی، گروه فیزیولوژی ورزش، دانشگاه تربیت دبیر شهید رجایی، تهران، ایران

چکیده

پژوهش حاضر با هدف بررسی تاثیر ۱۰ هفته تمرین تناوبی شدید بر مقاومت به انسولین و سطوح سرمی رزیستین در مردان دارای اضافه وزن و چاق انجام شد. ۱۸ مرد با میانگین سنی۳۶ /۲ ±۷ /۲۰ سال و شاخص توده بدن kg/m2 ۲۸/۷±۲/۶۸ به صورت تصادفی در دو گروه نه نفری شامل گروه کنترل و تمرین تناوبی شدید (HIIT) تقسیم بندی شدند. آزمودنی ها در گروه HIIT به مدت ۱۰ هفته و سه جلسه در هفته (۱۰ وهله دویدن یک دقیقه ای) در برنامه تمرینی شرکت کردند. شدت تمرین ۹۰-۸۰ درصد ضربان قلب هدف بود. ۴۸ ساعت بعد از جلسه آخر تمرین خونگیری در شرایط ناشتایی انجام گرفت. مقایسه تغییرات بین گروهی و درون گروهی به ترتیب با آزمون تحلیل کوواریانس و t زوجی انجام و معناداری در سطح ۰/۰۵>p در نظر گفته شد. نتایج بین گروهی نشان داد که تغییرات در هیچکدام از متغیرهای بررسی شده به جز وزن بدن (۰/۰۴۲=p) بین گروه HIIT و کنترل معنادار نبوده است. اما کاهش معنادار BMI

(۰/۰۰۲=p )، مقاومت به انسولین (۰/۰۲۹=p)، درصد چربی بدن (۰/۰۰۵=p) و وزن بدن (۰/۰۱=p) در گروه HIIT مشاهده شد. همچنین، VO2max در گروه HIIT به صورت معناداری افزایش یافت (001/0>p). باوجود این، تغییرات درون گروهی (۰/۳۸=p) و بین گروهی (۰/۴۵۹=p) سطوح رزیستین از نظر آماری معنادار نبود. نتایج حاضر نشان داد که HIIT نقش موثری در کاهش مقاومت به انسولین و بهبود ترکیب بدن در مردان دارای اضافه وزن و چاق دارد، که این اثرات مثبت HIIT مستقل از تغییرات در سطوح رزیستین اتفاق می افتد.

کلیدواژه‌ها


عنوان مقاله [English]

Changes in Insulin resistance and serum levels of resistin after 10 weeks high intensity interval training in overweight and obese men.

نویسندگان [English]

  • Shahin Riyahi Malayeri 1
  • Mohammadamin Saei 2
1 Department of physical education & sport science, Faculty of Humanities, East Tehran Branch, Islamic Azad University, Tehran, Iran.
2 Faculty of Sport Sciences, exercise physiology department, Shahid Rajaee Teacher Training University, Tehran, Iran.
چکیده [English]

present study was conducted to aim of investigate the effect 10 weeks high intensity interval training on serum levels of resistin and insulin resistance in overweight and obese males. Eighteen young men with average age of 20.5±2.15 yrs. and body mass index (BMI) 28.7±2.95 kg/m2 randomly divided in two groups (each group nine person) including control and high intensity interval training (HIIT) groups. Subject in HIIT group take part in training program for 10 weeks and three sessions per week (10 bouts of one minutes running). Exercise session intensity was 80-90 percent of target heart rate. 48 hours after last exercise session, fasting blood samples collected and serum levels of resistin and insulin resistance was measured. Data were analyzed by analysis of covariance and paired t test respectively and significance considered as p

کلیدواژه‌ها [English]

  • High Intensity Interval Training (HIIT)
  • Resistin
  • Insulin Resistance
  • Body Composition
1.   de Sousa CV, Sales MM, Rosa TS, Lewis JE, de Andrade RV, Simoes HG. The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis. Sports Med. 2017;47(2):277-93.
2.   Poortinga W. Perceptions of the environment, physical activity, and obesity. Soc Sci Med. 2006;63(11):2835-46.
3.   Davel AP, Wenceslau CF, Akamine EH, Xavier FE, Couto GK, Oliveira HT, et al. Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update. Braz J Med Biol Res. 2011;44(9):920-32.
4.   Sahin-Efe A, Katsikeris F, Mantzoros CS. Advances in adipokines. Metabolism. 2012;61(12):1659-65.
5.   Huffman KM, Slentz CA, Bales CW, Houmard JA, Kraus WE. Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention. Metabolism. 2008;57(4):577-83.
6.   Gustafson B. Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb. 2010;17(4):332-41.
7.   Balistreri CR, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm. 2010;2010:802078.
8.   Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gomez-Reino JJ, et al. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol. 2017;13(2):100-9.
9.   Nielsen NB, Hojbjerre L, Sonne MP, Alibegovic AC, Vaag A, Dela F, et al. Interstitial concentrations of adipokines in subcutaneous abdominal and femoral adipose tissue. Regul Pept. 2009;155(1-3):39-45.
10. Than A, Ye F, Xue R, Ong JW, Poh CL, Chen P. The crosstalks between adipokines and catecholamines. Mol Cell Endocrinol. 2011;332(1-2):261-70.
11. Conde J, Scotece M, Gomez R, Lopez V, Gomez-Reino JJ, Lago F, et al. Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. Biofactors. 2011;37(6):413-20.
12. Krysiak R, Handzlik-Orlik G, Okopien B. The role of adipokines in connective tissue diseases. Eur J Nutr. 2012;51(5):513-28.
13. Kim HS, Sung HY, Kim MS, Kim JL, Kang MK, Gong JH, et al. Oleanolic acid suppresses resistin induction in adipocytes by modulating Tyk-STAT signaling. Nutr Res. 2013;33(2):144-53.
14. Bing C, Gomez-Ambrosi J, Zabalegui N, Williams G, Trayhurn P. Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice. Biochem Biophys Res Commun. 2002;296(2):458-62.
15. Fernandez CM, Molto E, Gallardo N, del Arco A, Martinez C, Andres A, et al. The expression of rat resistin isoforms is differentially regulated in visceral adipose tissues: effects of aging and food restriction. Metabolism. 2009;58(2):204-11.
16. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307-12.
17. Chen N, Zhou L, Zhang Z, Xu J, Wan Z, Qin L. Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue. Regul Pept. 2014;194-195:49-54.
18. Barry JC, Simtchouk S, Durrer C, Jung ME, Little JP. Short-Term Exercise Training Alters Leukocyte Chemokine Receptors in Obese Adults. Med Sci Sports Exerc. 2017;49(8):1631-40.
19. You T, Nicklas BJ. Effects of exercise on adipokines and the metabolic syndrome. Curr Diab Rep. 2008;8(1):7-11.
20. Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care. 2007;30(3):719-21.
21. Rashidlamir A, Gholamian S, Ebrahimi Atri A, Seyyedalhoseyni M, Hesar Kooshki M. Effect of Regular Aerobic Exercise on Plasma Levels of Resistin and Adiponectin in Active Young Females. Journal of Mazandaran University of Medical Sciences. 2013;23(101):67-76.
22. Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol. 2012;590(5):1077-84.
23. Lazzer S, Tringali G, Caccavale M, De Micheli R, Abbruzzese L, Sartorio A. Effects of high-intensity interval training on physical capacities and substrate oxidation rate in obese adolescents. J Endocrinol Invest. 2017;40(2):217-26.
24. AfshounPour M, Davoodi Z, Habibi H, Ranjbar R, Shakerian S. The Effect of Circuit Resistance Exercise On Plasma Resistin Concentration and Insulin Resistance in Type 2 Diabetic Men. The Journal of Shahid Sadoughi University of Medical Sciences. 2015;23(8):770-81.
25. jazi AA, Gharehkhani M. The effect of aerobic exercise training on serum resistin levels and its relationship with insulin resistance in overweight elderly women. aspjournals. 2013;8(15):41-52.
26. Zahra S, Asghar T, Alireza M. Effect of 12 weeks of aerobic-resistance training on serum levels of resinsin and glycemic indices in obese women with type 2 diabetes. Iranian Journal of Diabetes and Lipid Disorders. 2013;12(6):524-33.
27. Dehghani K, Mogharnasi M, Talei Rudy M. The Effect of High-intensity Interval Training (HIIT) on Plasma Levels of Resistin in Male Non-athlete Students (A Trial Study). Qom Univ Med Sci J. 2015;9(11):33-40.
28. Bompa TO, Bompa TO. Periodization : theory and methodology of training. 4th ed. Champaign, IL: Human Kinetics; 1999. ix, 413 p. p.
29. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.
30. Dolgener FA, Hensley LD, Marsh JJ, Fjelstul JK. Validation of the Rockport Fitness Walking Test in college males and females. Res Q Exerc Sport. 1994;65(2):152-8.
31. Kazemi N, KOrdi MR, Noori R, Kasraeian M. Effect of Aerobic and Resistance Training on Resistin & Insulin Levels in Women with Gestational Diabetes. Sport Physiology. 2017;9(33):101-14.
32. A T, Z S, A M. Blood Levels of Resistin, Glycemic Indices and Lipid Profile in Women with Type 2 Diabetes. Journal of Diabetes & Metabolism. 2016;7(9).
33. Abdi A, Aohajer iravani O. The effect of Punica granatum L. along with aerobic training on resistin, serum adiponectin and insulin resistance in women with type 2 diabetes. Feyz Journal of Kashan University of Medical Sciences. 2018;22(1):39-47.
34. Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci. 2009;27(14):1607-15.
35. Souri R, Khosravi N, y h, a h. A Comparison of Moderate Intensity Continuous Training and High Intensity Interval Training on Serum Levels of Resistin and Insulin Resistance in Type-2 Diabetic Obese Women. Journal of Sport Biosciences. 2016;8(3):365-80.
36. Steckling FM, Farinha JB, Figueiredo FDC, Santos DLD, Bresciani G, Kretzmann NA, et al. High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome. Arch Physiol Biochem. 2018:1-7.
37. Marcelino-Rodriguez I, Almeida Gonzalez D, Aleman-Sanchez JJ, Brito Diaz B, Rodriguez Perez MDC, Gannar F, et al. Inverse association of resistin with physical activity in the general population. PLoS One. 2017;12(8):e0182493.
38. Jones TE, Basilio JL, Brophy PM, McCammon MR, Hickner RC. Long-term exercise training in overweight adolescents improves plasma peptide YY and resistin. Obesity (Silver Spring). 2009;17(6):1189-95.
39. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9(5):367-77.
40. Way KL, Hackett DA, Baker MK, Johnson NA. The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Diabetes Metab J. 2016;40(4):253-71.
41. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, et al. Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun. 2002;299(2):291-8.
42. Zhou L, Li Y, Xia T, Feng S, Chen X, Yang Z. Resistin overexpression impaired glucose tolerance in hepatocytes. European cytokine network. 2006;17(3):189-95.
43. Badoer E, Kosari S, Stebbing MJ. Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity. Front Physiol. 2015;6:321.