The Effect of Consumption of Quercetin Supplement on Gene Expression of PGC-1α during Sedentary Period in Active Rats after a HIIT Course

Document Type : Original Article

Authors

1 MSc Student of Exercise Nutrition, Educational Sciences and Psychology Faculty, Shiraz University, Shiraz, Iran

2 Associate Professor, Educational Sciences and Psychology Faculty, Shiraz University, Shiraz, Iran

3 The assistant professor of the faculty of education and psychology of Shiraz University, Shiraz, Fars

4 The PhD student of institute for the stem cell growth of Shiraz University of medical sciences, Shiraz, Iran

Abstract

 
The aim of this study was to determine the effect of Quercetin supplement during sedentary period on the signaling pathway of the PGC-1α. Researchers are trying to find out whether Quercetin supplement consumption can be beneficial to preventing atrophy during sedentary period. In this study, 30 male rats (age=2 months old, weight=295±11.80 g, Sprague-Dawley) were selected. They were assigned to 2 groups: control (n=6) and training (n=24). Interval training with the intensity of 16 m started in the first week and reached the speed of 30 m/min. in the eighth week. Then, the rats of the control group and 6 rats of the training group were killed. Then, the rest of training group (n=18) were randomly divided into 3 groups: detraining, sedentation and sedentation-Quercetin supplement. Sedentary groups became inactive for 14 days and Quercetin supplement group was fed with Quercetin (400 mg/day) during this period. After these 14 days, they were killed and the amount of the PGC-1α gene expression of their soleus muscle was measured. The mean weight of the rats was higher than the control and the other two groups (detraining and sedentation) (P=0.001). On the other hand, after 14 days, the sedentation-Quercetin group had the highest whereas the sedentation group had the lowest amount of PGC-1α gene expression (P=0.004). The results of the changes showed that the minimum reduction in the muscle weight and gene expression of the PGC1α during sedentary period can be expected by consuming Quercetin supplement.

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