The Effect of Omega-3 Supplementation with a Period of Selected Aerobic Exercises on Prostaglandin E2 (PGE2) Inflammatory Marker in Trained Female Students

Authors

1 MSc in Exercise Physiology, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran

2 Associate Professor in Exercise Physiology, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran

3 Assistant Professor in Exercise Physiology, Islamic Azad University, Ashtian Branch, Ashtian, Iran

Abstract

The aim of this study was to investigate the effect of omega- 3 supplementation including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) along with a period of selected aerobic activity on prostaglandin E2 (PGE2) inflammatory marker in trained female students for 6 weeks. For this purpose, 32 female students of physical education in Alzahra University (mean age 22.5+1.2 yr and body mass index 21.59+1.2 kg/m2) were selected and randomly divided into 4 groups: control, supplementation, exercise and supplementation with exercise. PGE2 was measured as the dependent variable at the beginning and the end of the study. Data were analyzed using paired t test, one-way ANOVA and Gabriel test. All tests were significant at 0.05. The results showed a significant difference in PGE2 between the control and exercise groups (P=0.035) and between control and supplementation + exercise groups (P=0.0001) while there were no significant differences between control and supplementation groups and between supplementation + exercise and exercise groups. According to these findings, serum level of PGE2 in supplementation, exercise and supplementation + exercise groups (P<0.05) significantly reduced in the intragroup comparison in posttest compared with the pretest.

Keywords


1.ام برگ ،جرمی.، تیشکو جان آل ، استرایر لوبر. (1388). "بیوشیمی استرایر". (محسن اصغری و همکاران،مترجم).خانه زیست شناسی.ویرایش ششم.تهران،273-268.
2.چوبینه ، سیروس . اکبرنژاد ،علی . برجیان، محبوبه. کردی، محمدرضا . (1391)."بررسی اثر مصرف مکمل امگا 3 بر مقدار سرمی پروستاگلاندین ای 2 پس از یک وهله فعالیت ورزشی درمانده‌ساز".نشریه علوم زیستی ورزشی، (شماره 15 )،   121-133
3. راست منش،سیدرضا.(1382)."تغذیه ورژیم درمانی بالینی".انتشارات الباب ،چاپ دوم.تهران،   277-276.
4. لنینجر،آلبرت (1385)."اصول بیوشیمی لنینجر".آییژ،شابک،821-822.
5. ماهان،ال کتلین .(1383)."اصول تغذیه کراوس".تهران،شابک،چاپ دوم ،67-65
6. ویلمور،جک.کاستیل،دیوید ال.(1388). "فیزیولوژی ورزش و فعالیت بدنی". (دکتر ضیاء معینی و همکاران، مترجم). تهران،مبتکران،چاپ هشتم،24.
7.Anderson, S. and E.Daviskas (2000). “The mechanism  exercisenducedasthma”.J Allergy ClinImmunol. 106(3): 453-459.
8.Andrade, P. et al. (2007). “Effects of the fish– oil supplementation on the immuneandinflammatory responses  in elite swimmers.ProstaglandinsLeukotEssent Fatty Acids. 77(3-4):139-45.
9. BanifG ,GolombiniA,Lombardi G and et al .(2012).Metabolic   markers1in sports medicine.Adv chin chem.56:1-54.
10.Conceição MS9-, Libardi CA.(2012).Effects of eccentric exercise on systemic concentrations of pro- and anti-inflammatory cytokines and prostaglandin (E2): comparison between young and postmenopausal women.Eur J Appl Physiol.112(9):3205-13.
11.Dyhr Toft  Anders, Thorn Mette , Ostrowski Kenneth and et al.(2000).N-3polyunsaturated fatty acids do not affect cytokine response to strenuous exercise.Journal of Applied Physiology.89(6):2401-6.
12.Ferrucci L, Cherubini A, Bandinelli S, et al.( 2006 ).Relationship of plasm polyunsaturated fatty acids to circulating inflammatory markers. J ClinEndocrinolMetab. 91(2):439-46.
13.Hyo JK, Yoon HL, Chang KK.(2007). Biomarkers of muscle and cartilage damage and inflammation during a 200 km run. Eur J ApplPhysiol.99(4):443-7
14.Kelly B. Jouris and et al.( 2011).The effect of omega-3 fatty acid supplementation on the inflammatory response to eccentric strength exercise.Journal of Sports Science and Medicine.10(3):432-8.

15.Kelley DSTaylor PCNelson GJ, and et al. 1999.Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men.Lipids. 34(4):317-324.

16.Lavie, C.J., Milani, R.V., Mehra, M.R. and Ventura, H.O. (2009) Omega-3 polyunsaturated fatty acids and cardiovascular diseases.Journal of the American College of Cardiology 54, 585-594.
17.Meydani SN, Endres S, Woods MM and et al. (1991).Oral (N-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation:comparison between young and older women. J Nutr. 121(4):547-55.
18.M Hill,Alison.(2007).DHA –Rich fish oil and regular moderate exercise:A combined intervention to improve cardiovascular,metabolic and inflammatory biomarkers in obesity.aThesis submitted for the degree of doctor of
philosophy.Discipline of physiology.university of Adelaide.south Australia.37-40.
19.Priscila MM, Ribeiroa BG, Bozzab MT, et al. (2007).Effects of the fish-oil supplementation on the immune and inflammatory responses in elite swimmers.ProstaglandinsLeukotEssent Fatty Acids. 77:139–145.
20. Schubert 41-Ralf, Ph.D, Kitz Richard,MD and et al. (2007).Influence of low-dose polyunsaturated fatty acids supplementation on inflammatory response of healthy adults Applied nutritional investigation. 23( 10): 724–730
21.Tartibian BMaleki BH and et al.(2011).’’Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study”. Nutrition & Metabolism. 15: 8-71
22.Tartibian BMaleki BH and et al.(2011).Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men.clinical journal of sport  medicine..21(2):131-7