Increasing participation of people in competitive, martial and recreational sports, the incidence of inflammation and muscle damage has also increased, and this leads to a lot of economic, mental and psychological damage to sports clubs and players. The aim of this study was to investigate the effect of comprehensive modified FIFA 11+ warm-up program on inflammatory indicators and muscle damage in adolescent taekwondo males. The current research was carried out as a semi-experimental type with a pre-test-post-test design, and the statistical population consisted of all the young taekwondo players aged 13 to 18 in Zanjan city who met the conditions to enter the research. 24 adolescent taekwondo practitioners with at least three years of sports experience were selected and randomly divided into two equal experimental and control groups. The experimental group in addition to their routine taekwondo exercises, used modified FIFA +11 warm-up exercises for warm-up, and the control group did their usual warm-up exercises. At the pretest, blood samples were taken to check muscle damage indicators levels, and the second stage of sampling was performed 24 hours after eight weeks. Analysis of covariance was used to compare the groups and the effect of the intervention; significance level was considered P<0.05. The results showed modified FIFA 11+ warm-up program had no significant difference on CPK, LDH and CRP (p value= 0.089, 0.543 and 0.729, respectively). The results of this research showed that modified FIFA 11+ warm- up program did not cause any damage or inflammation and can be recommended as a suitable and safe method for athletes and team coaches.