Objectives: Troponin type A and creatine phosphokinase MB are common markers of heart damage. It seems that different types of resistance training can have different effects on these markers. The purpose of this research is to investigate the effect of three resistance training systems (drop set, descending pyramid, and traditional) on the levels of the mentioned heart damage indicators.

Methods: The current research was semi-experimental of applied type with a one-group design. The study population of the present study was 14-16-year-old boy volleyball players from the city of Sabzevar, who had at least 2 years of experience in volleyball practice. Among them, 15 people were selected and tested as available samples. The subjects, on the day of the test, after testing weight, and height and also measuring a maximum repetition, the first stage of blood sampling was done. After 3 weeks of resistance training, the second stage of blood sampling was performed. Blood samples were immediately frozen and transferred to the laboratory where they were analyzed. The data were analyzed using variance analysis with repeated measurements with an error of 0.05 with SPSS-26 software.

results: By implementing the training protocol, it was concluded that the resistance training systems used in this plan have an effect on the levels of heart damage markers including cTn I and CPK-MB in the subjects based on the required intensity.

Conclusion: According to the findings of this research, it can be concluded that the drop set resistance training system due to the higher intensity caused a significant increase in the heart damage markers cTn I and CPK-MB.