This study aimed at evaluating the effect of 12 weeks of resistance training with high and moderate intensities on metabolic control in type 2 diabetic men.32 men with type 2 diabetes (mean age of 47.98±1.94 years) were randomly divided into three groups: moderate intensity (12 weeks of resistance training with 60-65% of one repetition maximum, 3 sets with 12 repetitions), high intensity (12 weeks of resistance training with 80-85% of one repetition maximum, 4 sets with 7 repetitions) and the control (no training).Blood samples were collected before and after the training program after 10 hours of overnight fasting. The ANOVA with repeated measures (within-group and between-group interactions) was used for data analysis. Insulin resistance, triglyceride and BMI did not change significantly.Glycated hemoglobin, LDL, HDL, body fat percent and muscular strength significantly improved in the experimental groups in comparison with the control group. FGF21 significantly increased in both experimental groups in the posttest and this increase was significant in comparison with the control group.Overall, it can be stated that resistance training, particularly resistance training with higher intensity, has a significant role in improving glycemic and lipid profiles in patients with type 2 diabetes.