The effect of six weeks of High intensity interval training (HIIT) and soy supplementation on miR-29 gene expression in the heart of ovariectomy rats

Document Type : Original Article

Authors

1 Assistant Professor, Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran

2 Prof.Department of exercise physiology, Faculty of Sport Sciences and Health, University of Tehran.Tehran , Iran

3 Prof, Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran

10.22034/spmi.2023.191095

Abstract

Abstract
The prevalence of heart disease in postmenopausal women is higher than men in their age group. The purpose of this study was to determine the effect of six weeks of High intensity interval training (HIIT) and soy supplementation on miR-29 gene expression in the heart of ovariectomized rats.
In this study, 30 Wistar rats were randomly selected and divided into 5 groups after ovariectomy surgery. High intensity interval training (HIIT) and soya supplement were done for 6 weeks. After 48 hours of the last workout, the heart is transferred to the lab. The amount of expression of the miR-29 gene in the method RT-PCR was measured. Data analysis was performed using one-way ANOVA and Tukey's post hoc test (p≤ 0. 05). The results showed that ovariectomy reduced the expression of the miR-29 gene. The expression of miR-29 gene in the hearts of ovariectomized rats in the group of "High intensity interval training (HIIT)" (m = 0.72) was significantly higher than the group of "combination of exercise and soy supplementation" (m = 0.61). (045/0 = p). The results of the present study showed that the effect of HIIT exercises and soy supplement alone is more effective than the combination of the two as an effective way to prevent heart disease in postmenopausal women.

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