Impaired blood circulation reduces oxygenation and leads to tissue hypoxia. The aim of this study was to investigate the effect of two methods of training with blood flow restriction and training in hypoxia conditions on the inflammatory factors of trained men. The current research was semi-experimental with a pre-test-post-test design. 30 active people of Ardabil city with a history of 6 months of activity and ages between 30 and 45 were randomly selected into 3 groups of aerobic exercise in hypoxia (10 people, A-Hypo), resistance training with blood flow restriction (10 people, R-BFR) and control (10 people, Control). 2 days after the briefing session, in the pre-test session that was held at the laboratory, descriptive indicators such as height, weight and body mass index were measured and recorded. The levels of acute reactive protein (CRP), tumor necrosis factor alpha (TNF-α), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were evaluated. Two groups of training in hypoxia and training with blood flow restriction for 8 weeks performed selected exercises under special conditions of their group. Analysis of covariance and Bonferroni post hoc test were used for inter-group comparisons and dependent t-test for intra-group effects. Data analysis was done using SPSS version 24 software at a significance level of 0.05. Eight weeks of training in hypoxia and training with blood flow restriction had a significant decrease in the levels of CRP, TNF-α, LDL and a significant increase in HDL in active men (P=0.001). Also, a significant difference was observed in both experimental groups compared to the pre-test stage (P=0.001). It seems that both protocols have the ability to adapt inflammatory and anti-inflammatory pathways and beneficial changes in lipid profile. Therefore, both sports programs (hypoxia and BFR) are recommended for active men.