abstract

Skeletal muscle and hippocampus are two active tissues in facing environmental stimuli. The present study was to investigate the difference response of PGC1α in skeletal muscle and hippocampus tissues to exercise and cold stimuli. Therefore, 27male Wistar rats (8weeks age, weight250 ± 30gr) after being familiarized with laboratory environment, they were randomly divided into tree control, swimming in water with balanced and cold temperature groups. Then, two training groups swam three days a week for six weeks according to the research protocol, and 48 hours after the cognitive and physical performance test, the rats were sacrificed. The real-time method was used to investigate the changes in PGC1α gene expression, and the one-way ANOVA test was used to analyze the statistical findings. The results of performance tests showed that both experimental groups had a significant increase in performance in cognitive and physical tests compared to the control group (P>0/001). Also, the levels of PGC1α in hippocampus and skeletal muscle were significantly increased in both swimming training groups compared to the control group (p=0/24 and p=0/027, respectively) and the expression of PGC1α in cold water swimming group was significantly higher than the swimming group in water with normal temperature (p=0/04). Changes in expression of PGC1α also had a moderate correlation in both tissues (P=0/032). finally, it seems that in response to the swimming training in cold water, the hypothalamus has increased the expression of PGC1α in skeletal muscle and hippocampus through adrenergic stimuli.