Sport Physiology & Management Investigations

Sport Physiology & Management Investigations

Resistance Training Induces Favorable Homeostasis of Vascular Factors: Simultaneous Reduction of 3-Nitrotyrosine and Serum VEGF-C in Type 2 Diabetes.

Document Type : Original Article

Authors
bagher Shoja Anzabi
ًReza Farzizadeh
Farnaz Farnaz Sifi Asgshahr
Sina Siahsuha
Sayeh Ghasemzadeh
Department of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
10.22034/spmi.2026.555296.2805
Abstract
Background and Objective: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease associated with increased oxidative stress and vascular dysfunction. The aim of this study was to investigate the effect of eight weeks of resistance training on the serum levels of Vascular Endothelial Growth Factor C (VEGF-C) and 3-Nitrotyrosine (H-NT3) in middle-aged women with T2DM.

Methods: This semi-experimental study utilized a pretest-posttest control group design and was conducted on 30 middle-aged women with T2DM. Participants were divided into an experimental group (resistance training, $n=15$) and a control group ($n=15$). The experimental group performed resistance training for eight weeks, three sessions per week, with an intensity progressively increasing from 40% to 75% of one-repetition maximum (1RM), following the overload principle. Serum levels of VEGF-C and H-NT3 were measured using the ELISA method. Data were analyzed using the Analysis of Covariance (ANCOVA) test for comparing adjusted post-test differences, with the significance level set at P<0.05.Findings.

Results: showed that eight weeks of resistance training led to a significant decrease in both serum VEGF-C (P<0.05) and H-NT3 (P<0.05) levels in the experimental group compared to the control group.

Conclusion: It can be concluded that the implementation of a course of resistance training is an effective intervention for improving vascular health in middle-aged diabetic women by reducing oxidative stress and favorably regulating vascular factors.
Keywords
Type 2 diabetes
resistance training
VEGF-C
H-NT3