The Effect of 8-week Aerobic Exercise with Spirulina Supplementation Consumption on Plasma levels of MDA, SOD and TAC in Men with Type 2 Diabetes

Document Type : Original Article

Authors

1 PhD student, Department of Physiology and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

2 Professor of Physiology and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

3 Associate Professor of Physiology and Sport Sciences, University of Tehran, Tehran, Iran

4 MSc student, Department of Physiology and Sport Sciences, University of Tehran, Tehran, Iran

Abstract

Influence of physical activity with supplement consumption on the decrease of free radicals effects is not well known during exercise. Spirulina(Herbal Supplement green algae – blue) is one of the richest sources of Protein and antioxidants. Thus, the purpose of this study was to investigate the effect of 8-week exercise with Spirulina consumption on peroxidant and antioxidants indicators (TAC, SOD, MDA) in men with type 2 diabetes. 32 sedentary men with type 2 diabetes participated in this study with average age of 40 years and with no history of regular exercise that were randomly divided into 4 groups: control (C), exercise (E), supplementation (S) and exercise + supplementation (E+S). Training programs were 45 minutes of aerobic exercise, 3 times in week with 60-65% of maximal heart rate. S and E+S groups consumed Daily 2 tablets of 500 mg Spirulina. Blood samples were taken in two phases (before and after 8 weeks) following 10 to 12 hours of being fasted. Results showed MDA decreased significantly, but SOD and CAT levels increased significantly in E, S, E+S groups after 8 weeks (P ≤ 0/05). Also there was a significant difference between MDA in E and E+S groups after 8 weeks (P ≤ 0/05).The results showed that regular aerobic exercise with Spirulina consumption can improve peroxidant and antioxidant balance in men with type 2 diabetes and prevent exercise-induced oxidative stress and also diabetes.

Keywords


1.            Mohajeri D, Doostar Y.Antioxidant effect of extract of the grape seed in streptozotocin induced diabetic rats. ZJRMS.2009; 12(1): 9-14.
2.            Alipour M, Salehi I, Ghadiri Soufi F. Effect of exercise on diabetes-induced oxidative stress in the rat hippocampus. Iran Red Crescent Med J. 2012; 14(4): 222-8.
3.            Radak Z, Chung H, Goto S. Systemic adaptation to oxidative challenging induced by regular exercise.Free Radic Biol Med.2008; 44:153-59 .
4.            Hozayen WG, Mahmoud AM, Soliman HA, Mostafa SR .Spirulina versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats. J Intercult Ethnopharmacol. 2016;5(1):57-64.
5.            Upasani CD, Balaraman R. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. Phytother Res. 2003;17(4):330-4.
6.            Gupta A, Nair  A, Kumria  R, Al-Dhubiab  BE, Chattopadhyaya  I , Gupta  SC. Assessment of pharmacokinetic interaction of spirulina with glitazone in a type 2 diabetes  rat model. J Med Food. 2013;16(12):1095-100.
7.            Lee EH, Park JE, Choi YJ, Huh KB, Kim WY.A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutr Res Pract. 2008;2(4):295-300.
8.            Fakoory Jouybari M, Farzanegi P, Barari A.The effect of 8-week aerobic exercise with purslane supplementation consumption on peroxidant and antioxidants indicators in women with type 2 diabetes. J Shahid Sadoughi Univ Med Sci.2014; 22(1): 928-39.
9.            Chen SC, Ueng KC, Lee SH, Sun KT, Lee MC. Effect of T’ai Chi exercise on biochemical profiles and oxidative stress indicators in obese patients with type 2 diabetes. J Altern Complement Med. 2010; 16(11): 1153-59.
10.         Mohammadi M, Salehi I, Farajnia SA.Effects of swimming exercise on oxidative stress in the hippocampus of male diabetic rats. J Tabriz Univ Med Sci. 2009; 30(2): 11-18.
11.         Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk. Circulation.2009; 119(25): 3244-62.
12.         Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA.Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res. 2005; 19(2): 276-85.
13.         Coskun O, Ocakci A, Bayraktaroglu T, Kanter M. Exercise training prevents and protects sterpetozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med. 2004; 203(3): 145-54.
14.         Teixeira-Lemos E, Nunes S, Teixeira F, Reis F.Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol.2011; 28(3): 10-19.
15.         Naghizadeh H, Banparvari M, Salehikia A.Effect of one course exercise with consumption vitamin E on antioxidant status and cardiovascular risk factors. ZJRMS.2010; 12(1): 33-39.
16.         Dong CX, Hayashi K, Lee JB, Hayashi T.Characterization of structures and antiviral effects of polysaccharides from portulaca oleracea L. Chem Pharm Bull. 2010; 58(4): 507-10.
17.         Aissaoui O, Amiali M, Bouzid N, Belkacemi K, Bitam A. Effect of Spirulina platensis ingestion on the abnormal biochemical and oxidative stress parameters in the pancreas and liver of alloxan-induced diabetic rats. Pharm Biol. 2017;55(1):1304-1312.
18.         Parikh P, Mani U, Iyer U.Role of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes Mellitus. J Med Food. 2001;4(4):193-199.
19.         Dabidi Roshan V, Moslehi Najafabadi E.The Effect of short-term vitamin E supplementation on some indexes of sport performances and lipid per-oxidation in healthy men. World J Sport Sci. 2009; 2(2): 75-81.