عنوان مقاله [English]
Cerebral ischemia is associated with extensive metabolic disorders in the nerve cells especially the hippocampal neurons. Evidence suggests that exercise have a neuroprotective effect and can protect the brain from ischemic injury. This study aimed to investigate effect of pre-ischemic exercise on lipid peroxidation and antioxidant enzymes activity in hippocampus. 21 male Wistar rats were randomly divided into three groups: sham, exercise + ischemia and ischemia. The rats in exercise group were trained to run on a treadmill 5 days a week for 4 weeks. Ischemia induced by occlusion both common carotid arteries for 20 minutes. Malondialdehyde (MDA) and antioxidant enzymes activity (SOD, GPX, and CAT) was measured using a special Kits. The results showed that exercise led to significant decrease MDA concentration and a significant increase antioxidant enzymes activity in the hippocampus. In conclusion, exercise by increasing the antioxidative enzymes activity may have a protective effect against ischemia-induced injuries and disorders.
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