عنوان مقاله [English]
Aerobic exercises are considered as an affecting factor on inflammatory indices and lipid profile. The present study examined the effect of aerobic exercises on IL-6 and TNF-α proteins and lipid profile in Male Rats. For this purpose, 18 healthy adult male rats were selected and divided into two groups: control groups (N = 8) and subjects groups (N = 10). Aerobic exercise protocol was carried out during 8 weeks period, 3 sessions per weeks and 27 to 32 minutes per session by the intensity of 60-80% of VO2max(speed 8-25 m /min) on the treadmill in a zero gradient. After 8 weeks blood and tissue sampling was performed.Levels of IL-6 (p = 0/01) decreased significantly in trained rats compared with controls groups. While there were no significant difference in TNF-α levels. On the other hand, total serum cholesterol (P = 0/004) decreased followed by aerobic exercise. However, changes in the other lipid profile indices were not significant. Therefore, we can conclude that Aerobic exercise may lead to reduced inflammatory response and improve the lipid profile indices.
10. ADAMS, V., MANGNER, N., GASCH, A., KROHNE, C., GIELEN, S., HIRNER, S., THIERSE, H.-J., WITT, C. C., LINKE, A. & SCHULER, G. (2008). Induction of MuRF1 is essential for TNF-α-induced loss of muscle function in mice. Journal of molecular biology,384; 48-59.
11. Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, et al. (2009). Major lipids, apolipoproteins, and risk of vascular disease. JAMA, 302 :1993-2000.
12.Booth FW, Gordon SE, Carlson CJ, Hamilton MT.(2000)Waging war on modern chronic diseases: primary prevention through exercise biology, Journal of Applied Physiology, vol. 88,no. 2, pp. 774–787.
13.Banz W, Maher M, Thompson W, et al.(2003)Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med (Maywood).;228(4):434–40.
14.CAPPELLI, K., FELICETTI, M., CAPOMACCIO, S., PIERAMATI, C., SILVESTRELLI, M. & VERINI-SUPPLIZI, A. (2009). Exercise-induced up-regulation of MMP-1and IL-8genes in endurance horses. BMC physiology,9-12.
15.Dunn A, Marcus B, Kampert J, et al. (1997).Reduction in cardiovascular disease risk factors: 6-month results from Project Active. Prev Med.;26(6):883–92.
16.Faramoushi M, Amir Sasan R, Sari Sarraf V, Karimi P. (2016).Cardiac fibrosis and down regulation of GLUT4 in experimental diabetic cardiomyopathy are ameliorated by chronic exposures to intermittent altitude. Journal of Cardiovascular and Thoracic Research;8(1):26-33. doi:10.15171/jcvtr.2016.05.
17.Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjoberg LB and Pedersen BK. (2004).Supplementation with vitamins C and E inhibits the release of interleukin- 6 from contracting human skeletal muscle. J Physiol 558: 633-645.
18. Gleeson T. T., Baldwin K. M. (1981). Cardiovascular response to treadmill exercise in untrained rats.J. Appl. Physiol.50, 1206–1211.
19.GUSTAFSON, B. & SMITH, U. (2006).Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1preadipocytes. Journalofbiological chemistry, 281, pp.9507-9517.
20.HANDSCHIN, C. & SPIEGELMAN, B. M. (2008). The role of exercise and PGC1α in inflammation and chronic disease. Nature, 454, 463-469.
21.Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B and Richter EA. (2003.)The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546: 299-305.
22.Harber, M P., Konopka, A R., Douglass, M D., Minchev, K., Leonard A. Kaminsky, L A., Trappe, T A. and Trappe, S. (2009).Aerobic exercise training improves whole muscle and single myofiber size and function in older women. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 297 (5) R1452-R1459; DOI: 10.1152/ajpregu.00354.
23. Kiens B, Lithell H. (1989).Lipoprotein metabolism influenced by traininginduced changes in human skeletal muscle. J Clin Invest.;83: 558–564.
24. Kraus W, Houmard J, Duscha B, et al. (2002).Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med.;347(19):1483–92.
25. LeMura L, von Duvillard S, Andreacci J, et al. (2000).Lipid and lipoprotein profiles, cardiovascular fitness, body composition, and diet during and after resistance, aerobic and combination training in young women. Eur J Appl Physiol.;82(5–6):451–8.
26. Libardi CA1, De Souza GV, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. (2010).Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc.;44(1):50-6. doi: 10.1249/MSS.0b013e318229d2e9
27.Lira, F. S., Yamashita, A. S., Uchida, M. C., Zanchi, N. E., Gualano, B., Martins, E., … Seelaender, M. (2010). Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile. Diabetology & Metabolic Syndrome,2, 31. http://doi.org/10.1186/1758-5996-2-31
28.Mann S, Beedie C, Jimenez A. (2014)Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports Med.;44(2):211-21. doi: 10.1007/s40279-013-0110-5.
29. MOGHARNASI, M., GAEINI, A. & SHEIKHOLESLAMI VATANI, D.(2010). Comparing the effects of two training methods of aerobic and anaerobic on some pre-inflammatory cytokines in adult male rats. IranianJournal of Endocrinology and Metabolism,11;191-198.
30. Myers, J.,Prakash, M., V. Froelicher,D.Do, S. Partington, and J. E.Atwood, (2002).Exercise capacity and mortality among men referred for exercise testing,The New England Journal of Medicine, vol. 346, no. 11, pp. 793–801.
31. Niess AM, Fehrenbach E, Lehmann R, Opavsky L, Jesse M, Northoff H and Dickhuth HH. (2003)Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise. European Journal of Applied Physiology89: 344-351, 2003
32. Nicklas, B. J., Hsu, F.-C., Brinkley, T. J., Church, T., Goodpaster, B. H., Kritchevsky, S. B., & Pahor, M. (2008). Exercise Training and Plasma C-reactive Protein and Interleukin-6 in the Elderly. Journal of the American Geriatrics Society,56(11), 2045–2052. http://doi.org/10.1111/j.1532-5415.2008.01994.x
33. NORTHOFF, H. & BERG, A. (1991) . Immunologic mediators as parameters of the reaction to strenuous exercise. Internationaljournalofsportsmedicine,12, S15-9.
34. Nybo L, Sundstrup E, Jakobsen M, et al. (2010).High-intensity training versus traditional exercise interventions for promoting health.Med Sci Sports Exerc.;42(10):1951–8.
35. O’Donovan G, Owen A, Bird S, et al. (2005).Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost. J Appl Physiol; 98(5):1619–25.
36. Olchawa B1, Kingwell BA, Hoang A, Schneider L, Miyazaki O, Nestel P, Sviridov D. (2004).Physical fitness and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 24(6):1087-91. Epub 2004 Apr 8.
37. PEDERSEN, B. K. & FEBBRAIO, M. A. (2008). Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiologicalreviews,881379-1408.
38. PLOMGAARD, P., PENKOWA, M. & PEDERSEN, B. K. (2005). Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles. ExercImmunolRev, 11, 53-63.
39. Soltani F, Daryanoosh F, Salesi M, Mohamadi M, Jafari H, Soltani A. (2013)The Effect of Eight Weeks of Aerobic exercises on Visfatin, IL-6 and TNF-α in Female Sprague Dawley Rats. ZUMS Journal; 21 (89) :30-39
40. Steensberg A, Febbraio MA, Osada T, Schjerling P, Van Hall G, Saltin B and Pedersen BK. (2001)Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 537: 633-639.