Myostatin and interleukin-6 play an effective role in responding to muscle contractions, regulating and stimulating muscle metabolism. The purpose of this study was to investigate the effect of six weeks of progressive resistance training with blood flow restriction on myostatin and interleukin 6 in male taekwondo athletes. In this semi-experimental study, 19 male taekwondo practitioners with average age (22.1±2 years), height (176.3±4.3 cm) and weight (72.8±3.3 kg) were randomly divided into three groups of resistance training group without blood flow restriction (BFR), resistance training with BFR and taekwondo training. Training was performed for 6 weeks and 3 days a week in three methods with the same training load. An inflatable cuff with a pressure of 110% of the arterial occlusion pressure was used for the lower body and upper body. Blood sampling was done one day before and 48 hours after the completion of the protocol. The data were analyzed using one-way analysis of variance and Tukey's post hoc test. The results showed that the mean of myostatin was significantly lower in the resistance training group with BFR than the other groups (p=0.001). No significant difference was observed between IL-6 values of different groups (p=0.127). Although myostatin alone cannot express muscle changes, resistance training with BFR provides physiological stimuli to reduce myostatin, which strategy may be useful for elite taekwondo athletes who face a lack of time for recovery due to multiple competitions.