Background & objectives: The study investigates the effects of combined exercise and royal jelly supplementation on changes in specific physical fitness and biochemical indicators in postmenopausal women with non-alcoholic fatty liver disease (NAFLD).

Methods: Twenty-three postmenopausal women with NAFLD were randomly assigned to two groups: exercise + supplement (N=11) , exercise + placebo ( N=12). Resistance exercises included 8 weeks, 3 sessions of 35-40 minutes, eight stations, followed by 10-15 minutes of rest, aerobic exercises with an intensity of 40-85% of the target heart rate in two-minute intervals with 45 seconds of rest. The groups consumed 500 mg of royal jelly supplement or placebo before exercise sessions. Physical fitness - biochemical tests were conducted 48 hours before and after the last exercise session. Statistical analysis was performed using repeated measures ANOVA in SPSS software with a significance level of p<0.05.

Results: The effect of exercise + supplement on Apo B (p=0.107) was not significant. A significant increase in HDL (p=0.005), decrease in LDL (p=0.027), TC (p=0.045), and TG (p=0.013) were observed in the exercise + supplement group compared to the other group. A significant increase in lower extremity muscle strength (p=0.008) was found in the exercise + placebo group. Despite significant improvement in aerobic fitness and dynamic balance in both groups, there was no significant interactive effect (p=0.407; p=0.806).

Conclusion: Combined exercise and royal jelly consumption have significant effects on lipid profile. Functional indicators improved in both groups. Further controlled studies may provide stronger scientific evidence.