Amyloid A and IL-10 play an important role in modulating systemic and local inflammation and preventing the exacerbation of proinflammatory responses. The aim of the present study was to study the effect of a period of resistance and aerobic training on serum levels of amyloid A protein, IL-10, and fasting glucose in men with abdominal obesity. In a quasi-experimental study, 24 middle-aged men with abdominal obesity participated and were randomly divided into two experimental and control groups (n=12). The resistance and aerobic training program was started for 12 weeks and three days a week with an intensity of 55% of one repetition maximum and 50% of maximum heart rate, respectively, and increased by 5% every two weeks. The research variables were measured before and after training. Analysis of covariance and paired t-test were used at a significance level of P<0.05. The results of the between-group analysis of covariance showed that the levels of amyloid A (P=0.001, F=488.14), glucose (P=0.001, F=0.65), insulin (P=0.001, F=215), and insulin resistance (P=0.001, F=153.28) were significantly reduced in the experimental group compared to the control group, and IL-10 levels were significantly increased (P=0.001, F=36.42). Paired t-test results also showed a significant increase in IL-10 (P=0.002, 14.87%), and a significant decrease in amyloid A (P=0.001, -8.44%), glucose (P=0.001, -16.7%), insulin (P=0.001, -18.4%), and insulin resistance (P=0.001, -31.01%) in response to exercise. It is likely that combined exercise affects serum amyloid A and IL-10 levels in people with abdominal obesity by improving insulin sensitivity and body composition factors.