بررسی آثار تمرینات شنا بر سطوح FGF23، &Klotho، هایپرتروفی پاتولوژیک قلبی و عملکرد قلبی در رت‌های نر مبتلا به نارسایی مزمن کلیه

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، دانشکدة تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران

2 استاد، دانشکدة تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران.

3 دانشیار، دانشگاه علوم پزشکی، تهران، ایران.

4 دانشیار، دانشکدة تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران.

چکیده

عوارض قلبی-عروقی از مهم‌ترین عوامل مرگ‌ومیر در بیماران مبتلا به نارسایی کلیه شناخته شده است. هدف از این تحقیق بررسی آثار تمرینات شنا بر سطوح 23FGF و &Klotho  هایپرتروفی پاتولوژیک و عملکرد قلبی در رت‌های نر مبتلا به نارسایی مزمن کلیه است. پژوهش از نوع تجربی است و از طرح پست تست، مقایسه با گروه کنترل استفاده شد و در دانشگاه تهران و مرکز قلب تهران به انجام رسید. 30 موش صحرایی نر ویستار (7-8 هفته) به‌طور تصادفی به سه گروه تمرین، کنترل و شم تقسیم شده و 20 سر از طریق 5/6Nx جراحی شدند. پروتکل به‌صورت تمرینات شنا و 3 جلسه در هفته بود که به 30 دقیقه تا یک ساعت در انتهای پژوهش رسید. تجزیه‌و‌تحلیل داده‌ها بعد از تأیید طبیعی بودن توزیع داده‌ها از طریق آزمون کلموگروف اسمیرنوف، از آزمون تحلیل واریانس یکراهه و آزمون تعقیبی بونفرونی برای بررسی تفاوت بین‌گروهی استفاده شد ( 05/0 P >). تمرین شنا در میزان هایپرتروفی تغییر معنادار ایجاد نکرد، اما در عملکرد قلبی تفاوت معنا‌دار ایجاد شد. کلوتو، فسفر سرم و پاراتیروئید نیز تغییر معنادار داشت. FGF23 با تمرین شنا کاهش یافت، اما تغییرات معنادار نبود. وضعیت کلسیم و ویتامین D سرم بهبود یافت، اما معنادار نبود (05/0P>). تمرین شنا در بیماران کلیوی می‌تواند به وضعیت بهبود مشکلات قلبی- عروقی ایجادشده بر اثر عوارض بیماری تأثیر مثبت بگذارد.

کلیدواژه‌ها

عنوان مقاله [English]

Effects of swimming exercises on FGF23, & Klotho levels, cardiac pathological hypertrophy and cardiac function of male rats CKD

نویسندگان [English]

  • Zahra Shahsavari 1
  • Rahman Soori 2
  • Shahram Rabbani 3
  • Siroos Choubine 4
  • Sina Rokhsati 1
1 Ph.D. Student, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
2 Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
3 Associate Professor of Medical Sciences, Tehran, Iran
4 Associate Professor, Faculty of Physical Education and Sport Sciences, University of Tehran
چکیده [English]

 The purpose of this study was to determine the effect of swimming training on pathological cardiac hypertrophy, cardiac function, FGF23 and &Klotho of male rats CKD. In this study, 30 male Wistar rats (7-8 week) were randomly divided into three groups: training, control, and sham. The renal disease model was induced in rats by a 5/6 nephrectomy (5/6-NX) procedure. The exercise protocol was administered incrementally, 2 sessions per week for eight weeks. Activities included warm-up and resistance training. Resistance training was a ladder exercise with 3 sets and 6 repetitions with percentages of body weight. One-way ANOVA and Bonferroni statistical methods were used for data analysis. Significance level was considered P <0.05. The results showed that swimming exercise reduced FGF23 and pathological cardiac hypertrophy but the results were not significant.  Plasma levels of Klotho and cardiac function were significantly increased in the training group compared with the control group. Exercise training significantly decreased serum phosphorus and serum parathormon in the Train group. Serum calcium and vitamin D status were improved but were not significant. Overall, the results showed that swimming exercise can have a significant effect on cardiac function and cardiovascular disease indices in chronic Kidney disease.

کلیدواژه‌ها [English]

  • Chronic KidneyDisease
  • Cardiac function
  • FGF23
  • Klotho protein
  • cardiac hypertrophy
  • Swimming exercise

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پژوهش های فیزیولوژی و مدیریت در ورزش
دوره 13، شماره 3
آذر 1400
صفحه 119-129

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