اثر تمرینات مقاومتی بر سطح سرمی ویسفاتین، مقاومت به انسولین، گلوکز و برخی شاخص‌های ترکیب بدنی در نوجوان چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی،گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم‌تربیتی و روانشناسی دانشگاه محقق اردبیلی،اردبیل، ایران

2 دانشیار فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم‌تربیتی و روانشناسی دانشگاه محقق اردبیلی، اردبیل، ایران

3 دانشیار فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم‌انسانی دانشگاه کاشان، کاشان

4 دانشجوی کارشناسی‌ارشد فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم‌تربیتی و روانشناسی دانشگاه محقق اردبیلی، اردبیل، ایران

چکیده

به نظر می‌رسد چاقی منجر به التهاب و نقص در عملکرد انسولین می‌شود. ورزش با تحریک ویسفاتین می‌تواند نقش شبه انسولینی داشته باشد. هدف از مطالعه حاضر بررسی اثر ده هفته تمرین مقاومتی بر سطح سرمی ویسفاتین و مقاومت به انسولین در نوجوانان چاق بود. در این مطالعه‌ نیمه‌تجربی، تعداد 16 نفر از نوجوانان پسر چاق با میانگین سن (61/0±94/17) سال و شاخص توده بدنی بین 30 تا 35kg/m2 ، به‌صورت هدفمند انتخاب و به‌طور تصادفی، به تساوی در دو گروه تجربی و شاهد قرار گرفتند. گروه تمرین، برنامة تمرین مقاومتی را با شدت 40 تا 85 درصد 1RM، سه جلسه در هفته، به مدت ده هفته اجرا کردند. قبل از شروع برنامه تمرینی و 48 ساعت پس از آخرین جلسه تمرین مقادیر ویسفاتین، شاخص‌های قندی و ترکیب‌بدنی اندازه‌گیری شد. تحلیل داده‌ها با استفاده از آزمون t وابسته و تحلیل کوواریانس در سطح معنی‌داری 05/0 P<انجام شد تحلیل داده‌‌ها نشان داد که بعد از ده هفته تمرین مقاومتی، سطح سرمی ویسفاتین پلاسما (001/0=P، 81/375=F)، مقاومت به انسولین (001/0=P، 87/196=F)، انسولین (001/0=P، 62/325=F)، گلوکز (001/0=P، 99/66=F) و درصد چربی (03/0=P، 57/5=F) در گروه تجربی نسبت به کنترل به‌طور معنی‌داری کمتر است. هرچند وزن (15/0=P، 26/2=F) و شاخص توده بدن (20/0=P، 81/1=F) در مقایسه بین‌گروهی با کاهش همراه بود، اما معنی‌دار نشد. به نظر می‌رسد تمرینات مقاومتی با اثر بر ویسفاتین پلاسما و تقویت عملکرد شبه ‌انسولینی آن، می‌تواند در بهبود شاخص‌های قندی و ترکیب‌بدنی در افراد چاق مؤثر باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of resistance training on serum visfatin, insulin resistance, glucose and some body composition indices in obese adolescents

نویسندگان [English]

  • Mohammad ebrahim Bahram 1
  • Roghaye Afroonde 2
  • Mohammad javad Pourvaghar 3
  • Hamed Ghiyami Taklimi 1
  • Soheila Hemmati 4
1 Ph.D. Students in Sports Physiology, Department of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
2 Associate Professor of Sports Physiology, Department of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
3 Associate Professor, Department of Physical Education and Sport Sciences, University of kashan, kashan, Iran
4 Master. Students in Sports Physiology Department of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
چکیده [English]

Obesity seems to lead to inflammation and impaired insulin function. Exercise can play a quasi-insulin role by stimulating visfatin. The aim of this study was to investigate the effect of 10 weeks resistance training on visfatin and insulin resistance in obese adolescents. In this semi-experimental study, 16 adolescent obese boys with Mean age (17.93±0.61) years a body mass index of 30 to 35 kg/m2 were purposefully selected and randomly and equally divided into experimental and control groups. The training group performed a resistance training program with an intensity of 40 to % 851RM, three sessions per week, for ten weeks. Before the start of the training program and 48 hours after the last training session, the values of visfatin, glycemic index and body composition were measured. Data analysis was performed using dependent t-test and covariance analysis at a significance level of P<0.05. Data analysis showed that after 10 weeks of resistance training, serum levels of plasma visfatin (P=0.001, F=375.81), insulin resistance (P=0.001, F =1967.87), insulin (P= 0.001, F= 325.62, glucose (P= 0.001, F=66.99) and fat percentage (P= 0.03, F= 5.57) in the experimental group in terms of control. You have less although weight (P=0.15, F=2.26) and body mass index (P=0.20, F=1.81) were associated with a decrease in intergroup comparison, it was not significant. Resistance training appears to be effective in improving glycemic index and body composition in obese individuals by acting on visfatin plasma and enhancing its insulin-like function.

کلیدواژه‌ها [English]

  • Visfatin
  • Obese Adolescents
  • Resistance Training
  • Insulin Resistance
  • Body Composition
  1. Martinelli I, Tomassoni D, Moruzzi M, Roy P, Cifani C, Amenta F, Tayebati SK. Cardiovascular changes related to metabolic syndrome: Evidence in obese zucker Rats. International Journal of Molecular Sciences. 2020; 21(6):2035.
  2. Daley AJ, Copeland RJ, Wright NP, Roalfe A, Wales JK. Exercise therapy as a treatment for psychopathologic conditions in obese and morbidly obese adolescents: A randomized, controlled trial. Pediatrics. 2006; 2126-134.
  3. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. The Journal of Clinical Endocrinology & Metabolism. 2004; 89(6)2: 548- 56.
  4. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011;11(2):85-97
  5. Uslu S, Kebapçı N, Kara M, Bal C. Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. 2012; 4(1):113-2.
  6. Aller R, De Luis D, Izaola O, Sagrado MG, Conde R, Velasco M, et al. Influence of visfatin on histopathological changes of non-alcholic fatty liver disease. Dig Dis Sci. 2009; 54(8):1772-7.
  7. Berndt J, Klöting N, Kralisch S, Kovacs P, Fasshauer M, Schön MR, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes. 2005; 54(10): 2911-6.
  8. Haus JM, Solomon TP, Marchetti CM, O’Leary VB, Brooks LM, Gonzalez F, Kirwan JP. Decreased visfatin after exercise training correlates with improved glucose tolerance. Med Sci Sports Exerc. 2009; 41:1255-60.
  9. Haider DG, Pleiner J, Francesconi M, Wiesinger GF, Müller M, Wolzt M. Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. J Clin Endocrinol Metab. 2006; 91(11); 4702-704.
  10. Luk T, Malam Z, Marshall JC. Pre‐B cell colony‐enhancing factor (PBEF)/ visfatin: a novel mediator of innate immunity. Journal of leukocyte biology. 2008; 83(4):804-16.
  11. Khoshkam F, Taghian F, Jalali-Dehkordi Kh. Effect of eight weeks of supplementation of omega-3 supplementation and TRX training on visfatin and insulin resistance in women with polycystic ovary syndrome. Iranian Journal of Midwifery and Infertility. 2018; 21(9):58-70.
  12. Tofighi A, Hamzezadeh S, Mehdizadeh A, Zolfaghari M. Plasma visfatin levels in women with type 2 diabetes: compare the effect of aerobic and resistance training. J Urmia Univ Med Sci. 2014; 25 (2):150-9.
  13. Fathi R, Aslani Moghanjoughi S, Talebi E, Safarzadeh A, Seighal H. Effect of eight-week resistance training on plasma visfatin levels and its relation to insulin resistance in insulin-resistant male rats. Iranian journal of Diabetes and Metabolism. 2015; 14(6): 390-8.
  14. Suri R, Rezaeian N, Nikoo K. Implementation of a 10-week resistance training with weights on the synthesis of serum levels of colony-enhancing factor-beta precursor cells / visfatin in obese middle-aged women have no effect. Exercise Physiology 2012; 3(12):59-76.
  15. Saghebjoo M, Daste gardi S, Afzalpour ME, Hedayati M. Effects of aerobic and resistance training on plasma visfatin levels in overweight women. journal Koomesh. 2011;13(2):225-32.
  16. Basami M, Ahmadizad S, Rahmani H, Nikseresht A. Effect of resistance exercise and its volume on plasma visfatin concentration and its relationship with insulin resistance index, interlukin-6 and growth hormone in men. J Sport Bioethics Sci. 2013; 5(9):33-41.
  17. Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, Kim SM. Effect of exercise training on plasma visfatin and eotaxin levels. European Journal Endocrinol. 157(4):437-42.
  18. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr. 1978; 40: 497-504.
  19. Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, Resende ES, Ropelle ER, Carvalheira JB, Espindola FS, Jorge PT. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011; 60(9):1244-52.

 

  1. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, Wagner O, Georg P, Prager R, Kostner K, Dunky A. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Archives of physical medicine and rehabilitation. 2005; 86(8):1527-33.

 

  1. Idris I, Al-Ubaidi F. Discordance between non-HDL cholesterol and LDL cholesterol levels in patients with diabetes without previous cardiovascular events. Diabetes Metab. 2010; 36(4):299-304.
  2. Ahmadizad S, Haghighi AH, and Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European Journal of Endocrinology. 2007; 157: 625-31.
  3. Lee SS, Kang S. Effects of regular exercise on obesity and type 2 diabete mellitus in Korean children: improvements glycemic control and serum adipokines level. Journal of physical therapy science. 2015; 27(6):1903-7.
  4. Imai SI, Kiess W. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Frontiers in bioscience: a journal and virtual library. 2009;14:2983.
  5. Bo S, Ciccone G, Baldi I, Gambino R, Mandrile C, Durazzo M, Gentile L, Cassader M, Cavallo-Perin P, Pagano G. Plasma visfatin concentrations after a lifestyle intervention were directly associated with inflammatory markers. Nutrition, Metabolism and Cardiovascular Diseases. 2009; 1;19(6):423-30.
  6. Mir P, Mir Z. Effect of 8 weeks pilates exercise on plasma visfatin and insulin resistance index in obese women. NJV. 2016; 3(8):1-12.
  7. Dyaneti M, Taghian F. Comparison of 12-week Combined Exercise Training on Vitamin D Intake on Serum Visfatin Levels and β-cell Function in Diabetic Overweight Women. Armaghane danesh. 2018; 23 (4):413-427.
  8. Hosseini-Kakhk SAR, Attarnejad Z, Haghighi AH. A comparison of the effects of two aquatic exercise sessions with different durationon adiponectinand insulinresistance in women with type 2 diabetes. J Sabzevar Univ Med Sci. 2014; 20(4): 563-72.
  9. Keikhosravi F, Hosseini SA, Hassanpour G, Noura M. The Effect of Eight Weeks Aerobic Training on C-Reactive Protein, Vaspin and Visfatin in Non-Athletic Men. Armaghane danesh. 2019;24(3):474-83.
  10. Lee KJ, Shin YA, Lee KY, Jun TW, Song W. Aerobic exercise training-induced decrease in plasma visfatin and insulin resistance in obese female adolescents. International journal of sport nutrition and exercise metabolism. 2010;20(4):275-81.
  11. Graham TE, Yang Q, Bluher M. Retinol-binding protein 4 and insulin resistance in lean,obese, and diabetic subjects. N Engl J Med. 2006; 90:338-44.
  12. Sommer G, Garten A, Petzold S, Beck-Sickinger AG, Blüher M, Stumvoll M, Fasshauer M. Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clinical Science. 2008; 115(1):13-23.
  13. Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, Pekala PH, Dohm GL. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical Journal. 1990; 270 (2):397-400.
  14. Erdem G, Naharci Mi, Demirtaş A, Erçin Cn, Tapan S, Taşçi İ, et al. Therapeutic lifestyle change intervention in metabolic syndrome decreases plasma visfatin levels. Anatol J Clin Investig. 2008; 2(2):58-62.

34 Winnick JJ, Gaillard T, Schuster DP. Resistance training differentially affects weight loss and glucose metabolism of White and African American patients with type 2 diabetes mellitus. Ethnicity and Disease. 2008; 18(2):152.

35.Taghian F, Zolfaghary M, Hedayati M. Effect of 12 weeks aerobic exercise on visfatin level and insulin resistance in obese women. RJMS. 2014; 20(116):35-44.

  1. Byrd R, Chandler TJ, Conley MS, Fry AC, Haff GG, Koch A, et al. Strength training: single versus multiple sets. Sports medicine (Auckland, NZ). 1999; 27(6): 409.