نویسندگان
1 استادیار گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران
2 کارشناس ارشد گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران
3 استادیار گروه فیزیولوژی ورزشی، واحد ساری، دانشگاه آزاد اسلامی، ساری، ایران
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
The aim of the present study was the effect of 8 weeks of aerobic exercise on serum levels of FGF21, Apolipoprotein A-1 and LDL-C to HDL-C ratio in obese women. 20 obese women (age 30.25 ± 1.97 yr, height 1.61 ± 0.06 m, weight 85.29 ± 6.67 kg, BMI 32.72 ± 1.91 kg/m2) were randomly divided into 2 groups: aerobic exercise and control. Subjects in the experimental group performed aerobic exercise at intensity of 60-75% target heart rate for 8 weeks, 3 days per week for 30-45 minutes. Analysis of variance with repeated measures was used to analyze the data. Significant difference at P˂0.05 was accepted. The results showed that serum levels of FGF21 in the exercise group significantly increased (P=0.008) after 8 weeks of exercise but this increase was not significant compared to the control group. Also, serum levels of APO A-1 significantly increased (P=0.021) in the exercise group after 8 weeks of exercise but this increase was not significant compared to the control group. The ratio of LDL-C to HDL-C significantly reduced (P=0.011) after 8 weeks of aerobic exercise. It is possible that aerobic exercise can help prevent many diseases associated with obesity through a probable increase in FGF21 as well as a reduction in LDL-C to HDL-C ratio.
کلیدواژه‌ها [English]
10.Goodpaster, B.H, Katsiaras, A, and Kelley, D.E, (2003). Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes, 52(9): p. 2191-2197.
11.Hovingh, G.K., Wijland, M, Brownlie, A, et al, (2003). The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. Journal of lipid research, 44(6): p. 1251-1255.
12.Hui, X, Lam, K, Vanhoutte, P.M, et al, (2012). Adiponectin and cardiovascular health: an update. British journal of pharmacology, 165(3): p. 574-590.
13.Inagaki, T, Dutchak, P, Zhao, G, et al, (2007). Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21. Cell metabolism, 5(6): p. 415-425.
14.Khabazian, B.M, Ghanbari-Niaki, A, (2009). Endurance training enhances ABCA1 expression in rat small intestine. European journal of applied physiology, 107(3): p. 351-358.
15.Kharitonenkov, A, Shiyanova, TL, Koester, A, et al, (2005). FGF-21 as a novel metabolic regulator. Journal of Clinical Investigation, 115(6): p. 1627-1635.
16.Klein, I, Sarkadi,B, and Váradi, A, (1999). An inventory of the human ABC proteins. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1461(2): p. 237-262.
17.Knight, B, (2004). ATP-binding cassette transporter A1: regulation of cholesterol efflux. Biochemical Society Transactions, 32(1): p. 124-127.
18.Kraus, W.E, Houmard, JA, Duscha, BD, et al, (2002). Effects of the amount and intensity of exercise on plasma lipoproteins. New England Journal of Medicine, 347(19): p. 1483-1492.
19.Lambers, S, Laethem, C, Acker, K, et al, (2008). Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation, 22(6): p. 483-492.
20.Li, LI, Tang, L, (2015). Multiple Roles of Fibroblast Growth Factor 21 in Metabolism. Curr Pharm Des. Feb 12.
21.Li, X, Ge, H, Weiszmann, J, et al, (2009). Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in mice. FEBS letters, 583(19): p. 3230-3234.
22.Lundåsen, T, Hunt, MC, Nilsson, LM, et al, (2007). PPARα is a key regulator of hepatic FGF21. Biochemical and biophysical research communications, 360(2): p. 437-440.
23.Mai, K., Andres, J, Biedasek, K, et al, (2009). Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes, 58(7): p. 1532-1538.
24.Marinou, K., Tousoulis, D, Antonopoulos, AS, et al, (2010). Obesity and cardiovascular disease: from pathophysiology to risk stratification. International journal of cardiology, 138(1): p. 3-8.
25.Rahimi, N, marandi, S, Kargarfard, M, (2011). The effect of eight weeks aquatic training on lipid profile of patients who suffer from type ii diabetes. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), Volume 29, Number 148; Page(s) 988 To 996.
26.Ruaño, G, Seip, RL, Windemuth, A, et al, (2006). Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training. Atherosclerosis, 185(1): p. 65-69.
27.Sahoo, D, Trischuk, TC, Chan, T, et al, (2004). ABCA1-dependent lipid efflux to apolipoprotein AI mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes. Journal of lipid research, 45(6): p. 1122-1131.
28.Uebanso, T, Taketani, Y, Yamamoto, H, et al, (2011). Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? PLoS One, 6(8): p. e22976.
29.Véniant, M.M, Hale, C, Helmering, J, et al, (2012). FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One, 7(7): p. e40164.
30.Wilson, GJ, Lennox, BA, She, P, et al, (2015). GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab. 15; 308(4):E283-93.
31.You, T, and Nicklas,B,(2008). Effects of exercise on adipokines and the metabolic syndrome. Current diabetes reports, 8(1): p. 7-11.
32.Zhang, X, Yeung, D, Karpisek, M, et al, (2008). Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes, 57(5): p. 1246-1253.
)