پاسخ سطوح سرمی عامل رشد فیبروبلاست-2 و عامل رشد تغییردهندۀ-بتا به تمرین مقاومتی برون‌گرا با و بدون محدودیت جریان خون در مردان جوان فعال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی ( گرایش قلب و عروق ) ، گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 استادیار گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

3 استاد دانشگاه شهید بهشتی، دانشکدة تربیت بدنی، تهران، ایران

4 مرکز تحقیقات فیزیولوژی ورزشی، پژوهشکده سبک زندگی، دانشگاه علوم پزشکی، بقیه الله (عج)، تهران، ایران

چکیده

 
مطالعات زیادی پاسخ شاخص‌های سرمی آنژویوژنز را به تمرینات مقاومتی برون‌گرا با محدودیت جریان خون بررسی کرده‌اند. هدف از تحقیق حاضر بررسی پاسخ سطوح سرمی عامل رشد فیبروبلاست-2 (FGF-2) و عامل رشد تغییردهندۀ-بتا (TGF-β) به تمرین مقاومتی برون‌گرا با و بدون محدودیت جریان خون در مردان جوان فعال است. بدین‌منظور، 16مرد سالم با میانگین سنی 85/2 ± 8/27 سال به‌طور تصادفی انتخاب و به دو گروه تمرین مقاومتی برون‌گرای کم‌شدت با BFR و برون‌گرای پرشدت بدون BFR تقسیم شدند. گروه تمرین برون‌گرای پرشدت بدون BFR سه تا پنج دورۀ انقباض برون‌گرای عضلات چهارسر ران را با شدت70 تا 80 درصد حداکثر انقباض ارادی، به‌ترتیب با 30، 15، 15، 15 و 15 تکرار و 45 تا 60 ثانیه استراحت بین دوره‌ها تا مرحلۀ واماندگی انجام دادند. گروه تمرین مقاومتی برون‌گرای کم‌شدت بدون BFR همین پروتکل را با شدت 20 تا 30 درصد حداکثر انقباض ارادی اجرا کردند. پیش و پس از تمرین، به‌منظور سنجش سطوح سرمی دو عامل FGF-2 و TGF-β از ورید بازویی به‌روش الایزا نمونۀ خونی گرفته شد. داده‌ها با استفاده از آزمون‌های آماری تی زوجی و تحلیل واریانس با اندازه‌گیری مکرر در سطح معنا‌داری 05/0 P≤تجزیه‌وتحلیل شدند. یافته‌ها نشان می‌دهد یک جلسه تمرین مقاومتی کم‌شدت با BFR و پرشدت بدون BFR تأثیر معناداری بر سطوح سرمی (FGF-2) و (TGF-β) در مردان جوان فعال ندارد. به‌نظر می‌رسد دو مداخلۀ فعالیت ورزشی مقاومتی به‌کاررفته، تحریک کافی برای تغییر شاخص‌های تحریک‌کننده و مهاری آنژیوژنز را نداشته است.

کلیدواژه‌ها

عنوان مقاله [English]

Response of serum levels of Fibroblast Growth Factor-2 and Transforming Growth Factor-β to Eccentric Resistance Training with and without BFR in Active Young Men

نویسندگان [English]

  • Mohammad Eslamdoust 1
  • Farshad Ghazalian 2
  • Mandana Gholami 2
  • Khosro Ebrahim 3
  • Behzad Bazgir 4
1 PhD Student in Exercise Physiology (cardiovascular branch) , Islamic Azad University, Science and Research Branch, Department of Physical Education, Tehran, Iran
2 Assistant Professor, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 Professor at Shahid Beheshti University, Faculty of Physical Education, Tehran, Iran
4 Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده [English]

 
Many studies have investigated the response of angiogenesis serum index to eccentric resistance training with blood flow restriction. Therefore, the aim of the present study was to investigate the response of serum levels of fibroblast growth factor (TGFβ) and β - β (FGFβ) growth factor in eccentric resistance training with and without blood flow restriction in young males. 16 healthy males with a mean age of 22.6 ± 7.7 years were randomly selected and divided into two groups of resistance training with low and high intensity training. The exercise group without BFR resulted in the maximum executed 3-5 set of voluntary contraction intensive eccentric resistance exercise, 30, 15, 15, 15, 15 with 45 to 60 second rest interval at 70-80% maximum voluntary contraction, while low intensity resistance exercise with blood flow restriction did the exact previous exercise modality, but with an intensity 20-30% maximum voluntary contraction. The blood sample was taken before and after the exercise intervention from the brachial vein to measure the serum levels of TGF – β and FGF-2 in the with ELISA method. The collected Data analyzed using paired t statistical tests, one way analysis of variance with repeated measurements at P˂0. 05 significant levels. The results show that both resistance training sessions with and without BFR did not change TGF-β FGF-2 in active young men. According to the research findings, it seems that both resistance exercise interventions are not sufficient stimuli to induce enough to change in the stimulatory and inhibitory angiogenesis indicators.

کلیدواژه‌ها [English]

  • Keywords: Active men
  • BFR
  • Transforming growth factor-β (TGF-β)
  • Fibroblast growth factor-2 (FGF-2)

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پژوهش های فیزیولوژی و مدیریت در ورزش
دوره 13، شماره 2
شهریور 1400
صفحه 93-106

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