نوع مقاله : مقاله پژوهشی
1 دانشجوی دکتری فیزیولوژی ورزشی ( گرایش قلب و عروق ) ، گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
2 استادیار گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
3 استاد دانشگاه شهید بهشتی، دانشکدة تربیت بدنی، تهران، ایران
4 مرکز تحقیقات فیزیولوژی ورزشی، پژوهشکده سبک زندگی، دانشگاه علوم پزشکی، بقیه الله (عج)، تهران، ایران
عنوان مقاله [English]
Many studies have investigated the response of angiogenesis serum index to eccentric resistance training with blood flow restriction. Therefore, the aim of the present study was to investigate the response of serum levels of fibroblast growth factor (TGFβ) and β - β (FGFβ) growth factor in eccentric resistance training with and without blood flow restriction in young males. 16 healthy males with a mean age of 22.6 ± 7.7 years were randomly selected and divided into two groups of resistance training with low and high intensity training. The exercise group without BFR resulted in the maximum executed 3-5 set of voluntary contraction intensive eccentric resistance exercise, 30, 15, 15, 15, 15 with 45 to 60 second rest interval at 70-80% maximum voluntary contraction, while low intensity resistance exercise with blood flow restriction did the exact previous exercise modality, but with an intensity 20-30% maximum voluntary contraction. The blood sample was taken before and after the exercise intervention from the brachial vein to measure the serum levels of TGF – β and FGF-2 in the with ELISA method. The collected Data analyzed using paired t statistical tests, one way analysis of variance with repeated measurements at P˂0. 05 significant levels. The results show that both resistance training sessions with and without BFR did not change TGF-β FGF-2 in active young men. According to the research findings, it seems that both resistance exercise interventions are not sufficient stimuli to induce enough to change in the stimulatory and inhibitory angiogenesis indicators.
.4 Loenneke J. P. , T. R. S., Abe T. (2014). "Does blood flow restriction result in skeletal muscle damage? A critical review of available evidence." Scand J Med Sci Sports 1-8
.5 Neto G.R., Sousa MSC, Costa e Silva GV, Gil ALS, Salles BF, Novaes JS. Acute resistance exercise with blood flow restriction effects on heart rate, double product, oxygen saturation and perceived exertion. Clin Physiol Funct Imaging, 2016; 36: 53-59
.19 Schuster N, Krieglstein K. Mechanisms of TGF-β-mediated apoptosis. Cell and tissue research. 2002;307(1):1-14.
.20 Heinemeier K, Langberg H, Olesen JL, Kjaer M. Role of TGF-β1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue. Journal of Applied Physiology. 2003;95(6):2390-7.
.21 Massagué J. TGFβ signalling in context. Nature reviews Molecular cell biology. 2012;13(10):616.
.22 Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, et al. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013;62(8):2717-27.
.23 Kim E, Gregg LD, Kim L, Sherk VD, Bemben MG, Bemben DA. Hormone responses to an acute bout of low intensity blood flow restricted resistance exercise in college-aged females. Journal of sports science & medicine. 2014;13(1):91.
.24 Nielsen JL, Aagaard P, Bech RD, Nygaard T, Hvid LG, Wernbom M, et al. Proliferation of myogenic stem cells in human skeletal muscle in response to low‐load resistance training with blood flow restriction. The Journal of physiology. 2012;590(17):4351-61.
.25 Takano H, Morita T, Iida H, Asada K-i, Kato M, Uno K, et al. Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. European journal of applied physiology. 2005;95(1):65-73.
.26 Fujita T, WF B, Kurita K, Sato Y, Abe T. Increased muscle volume and strength following six days of low-intensity resistance training with restricted muscle blood flow. International Journal of KAATSU Training Research. 2008;4(1):1-8.
.27 Moriggi Jr R, Di Mauro H, Dias S, Matos J, Urtado M, Neto NCIS, et al. Similar hypotensive responses to resistance exercise with and without blood flow restriction. Biology of sport. 2015;32(4):289.
.28 Wanserski EM. POST EXERCISE BLOOD PRESSURE RESPONSE TO EXERCISE WITH BLOOD FLOW RESTRICTION.
.29 Manini TM, Clark BC. Blood flow restricted exercise and skeletal muscle health. Exercise and sport sciences reviews. 2009;37(2):78-85.
.30 Kumagai K, Kurobe K, Zhong H, Loenneke J, Thiebaud R, Ogita F, et al. Cardiovascular drift during low intensity exercise with leg blood flow restriction. Acta Physiologica Hungarica. 2012;99(4):392-9.
.31 Larkin KA, MacNeil RG, Dirain M, Sandesara B, Manini TM, Buford TW. Blood flow restriction enhances post–resistance exercise angiogenic gene expression. Medicine and science in sports and exercise. 2012;44(11):2077.
.32 Patterson SD, Ferguson RA. Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women. European journal of applied physiology. 2010;108(5):1025-33.
.33 Takarada Y, Sato Y, Ishii N. Effects of resistance exercise combined with vascular occlusion on muscle function in athletes. European journal of applied physiology. 2002;86(4):308-14.
.34 Burgomaster KA, Moore DR, Schofield LM, Phillips SM, Sale DG, Gibala MJ. Resistance training with vascular occlusion: metabolic adaptations in human muscle. Medicine and science in sports and exercise. 2003;35(7):1203-8.
.35 Reeves GV, Kraemer RR, Hollander DB, Clavier J, Thomas C, Francois M, et al. Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion. Journal of applied physiology. 2006;101(6):1616-22.
.36 Tanimoto M, Madarame H, Ishii N. Muscle oxygenation and plasma growth hormone concentration during and after resistance exercise: Comparison between “KAATSU” and other types of regimen. International Journal of KAATSU Training Research. 2005;1(2):51-6.
.37 Nocito A, Thöny S, Bächler T, Boutellier U, Wenger RH, Toigo M. Combined whole-body vibration, resistance exercise, and sustained vascular occlusion increases PGC-1α and VEGF mRNA abundances. European journal of applied physiology. 2013;113(4):1081-90.